ArticleMolecular biology and evolution2017
Spontaneous Mutation Rate in the Smallest Photosynthetic Eukaryotes.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 83 citations in OpenAlex.
- Interchromosomal Translocations and Large Deletions Drive the Evolution of the Outlier Chromosome in the Smallest Photosynthetic Eukaryote.Genome biology and evolution · 2026Article
- Splicing deficiency is driven by genomic erosion in non-recombining algal mating-type chromosomes.PLoS biology · 2026Article
- Spontaneous Mutations Occur More in Highly Transcribed Regions in Daphnia.Genome biology and evolution · 2026Article
- Extensive splicing deficiency in a degenerating mating-type chromosome.bioRxiv : the preprint server for biology · 2025Article
- Flipping the switch on some of the slowest mutating genomes: Direct measurements of plant mitochondrial and plastid mutation rates in msh1 mutants.PLoS genetics · 2025Article
- Low Mutation Rate and Atypical Mutation Spectrum in Prasinoderma coloniale: Insights From an Early Diverging Green Lineage.Genome biology and evolution · 2025Article
- Flipping the switch on some of the slowest mutating genomes: Direct measurements of plant mitochondrial and plastid mutation rates inbioRxiv : the preprint server for biology · 2025Article
- Protists and protistology in the Anthropocene: challenges for a climate and ecological crisis.BMC biology · 2024Review
- H3K4me1 recruits DNA repair proteins in plants.The Plant cell · 2024Article
- Prognostic analysis of mutated genes and insight into effects of DNA damage and repair on mutational strand asymmetries in gastric cancer.Biochemistry and biophysics reports · 2024Article
- Enhancing cold resistance in Banana (Musa spp.) through EMS-induced mutagenesis, L-Hyp pressure selection: phenotypic alterations, biomass composition, and transcriptomic insights.BMC plant biology · 2024Article
- Low Spontaneous Mutation Rate in Complex Multicellular Eukaryotes with a Haploid-Diploid Life Cycle.Molecular biology and evolution · 2023Article
- Similar mutation rates but different mutation spectra in moderate and extremely halophilic archaea.G3 (Bethesda, Md.) · 2023Article
- Very Low Rates of Spontaneous Gene Deletions and Gene Duplications in Dictyostelium discoideum.Journal of molecular evolution · 2023Article
- Rates and spectra of de novo structural mutations inGenome research · 2023Article
- Long-Term Stability of Bacterial Associations in a Microcosm ofFrontiers in plant science · 2022Article
- Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus.Nature communications · 2021Article
- Phytoplankton biodiversity and the inverted paradox.ISME communications · 2021Article
- Evolutionary Genomics of Sex-Related Chromosomes at the Base of the Green Lineage.Genome biology and evolution · 2021Article
- A neutral model for the loss of recombination on sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation is the ultimate source of genetic variation, and knowledge of mutation rates is fundamental for our understanding of all evolutionary processes. High throughput sequencing of mutation accumulation lines has provided genome wide spontaneous mutation rates in a dozen model species, but estimates from nonmodel organisms from much of the diversity of life are very limited. Here, we report mutation rates in four haploid marine bacterial-sized photosynthetic eukaryotic algae; Bathycoccus prasinos, Ostreococcus tauri, Ostreococcus mediterraneus, and Micromonas pusilla. The spontaneous mutation rate between species varies from μ = 4.4 × 10-10 to 9.8 × 10-10 mutations per nucleotide per generation. Within genomes, there is a two-fold increase of the mutation rate in intergenic regions, consistent with an optimization of mismatch and transcription-coupled DNA repair in coding sequences. Additionally, we show that deviation from the equilibrium GC content increases the mutation rate by ∼2% to ∼12% because of a GC bias in coding sequences. More generally, the difference between the observed and equilibrium GC content of genomes explains some of the inter-specific variation in mutation rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.