ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2018
Local activation time sampling density for atrial tachycardia contact mapping: how much is enough?
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 17 citations in OpenAlex.
- A Novel Workflow for Electrophysiology Studies in Patients with Brugada Syndrome.Sensors (Basel, Switzerland) · 2024Article
- Atrial conduction velocity mapping: clinical tools, algorithms and approaches for understanding the arrhythmogenic substrate.Medical & biological engineering & computing · 2022Review
- Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers.Frontiers in physiology · 2022Article
- Intracardiac Inverse Potential Mapping Using the Method of Fundamental Solutions.Frontiers in physiology · 2022Article
- Initial multicenter experience with a new high-density coloring module: impact for complex atrial arrhythmias interpretation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- OpenEP: A Cross-Platform Electroanatomic Mapping Data Format and Analysis Platform for Electrophysiology Research.Frontiers in physiology · 2021Article
- Utility of a ripple map for the interpretation of atrial propagation during atrial tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2019Article
- A work flow to build and validate patient specific left atrium electrophysiology models from catheter measurements.Medical image analysis · 2018Article
- Impact of recording technologies on cardiac electrogram morphology: implications for mapping and interpretation.Indian pacing and electrophysiology journalReview
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Aims: Local activation time (LAT) mapping forms the cornerstone of atrial tachycardia diagnosis. Although anatomic and positional accuracy of electroanatomic mapping (EAM) systems have been validated, the effect of electrode sampling density on LAT map reconstruction is not known. Here, we study the effect of chamber geometry and activation complexity on optimal LAT sampling density using a combined in silico and in vivo approach. Methods and results: In vivo 21 atrial tachycardia maps were studied in three groups: (1) focal activation, (2) macro-re-entry, and (3) localized re-entry. In silico activation was simulated on a 4×4cm atrial monolayer, sampled randomly at 0.25-10 points/cm2 and used to re-interpolate LAT maps. Activation patterns were studied in the geometrically simple porcine right atrium (RA) and complex human left atrium (LA). Activation complexity was introduced into the porcine RA by incomplete inter-caval linear ablation. In all cases, optimal sampling density was defined as the highest density resulting in minimal further error reduction in the re-interpolated maps. Optimal sampling densities for LA tachycardias were 0.67 ± 0.17 points/cm2 (focal activation), 1.05 ± 0.32 points/cm2 (macro-re-entry) and 1.23 ± 0.26 points/cm2 (localized re-entry), P = 0.0031. Increasing activation complexity was associated with increased optimal sampling density both in silico (focal activation 1.09 ± 0.14 points/cm2; re-entry 1.44 ± 0.49 points/cm2; spiral-wave 1.50 ± 0.34 points/cm2, P < 0.0001) and in vivo (porcine RA pre-ablation 0.45 ± 0.13 vs. post-ablation 0.78 ± 0.17 points/cm2, P = 0.0008). Increasing chamber geometry was also associated with increased optimal sampling density (0.61 ± 0.22 points/cm2 vs. 1.0 ± 0.34 points/cm2, P = 0.0015). Conclusion: Optimal sampling densities can be identified to maximize diagnostic yield of LAT maps. Greater sampling density is required to correctly reveal complex activation and represent activation across complex geometries. Overall, the optimal sampling density for LAT map interpolation defined in this study was ∼1.0-1.5 points/cm2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.