ArticleMolecular biology and evolution2017
Genome-Wide Identification of the Mutation Underlying Fleece Variation and Discriminating Ancestral Hairy Species from Modern Woolly Sheep.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 94 citations in OpenAlex.
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- Comparative histomorphometric and transcriptomic analysis reveals potential genetic determinants of pelage variation between hairy and coarse-woolly sheep.BMC genomics · 2025Article
- Genomic Diversity of U.S. Katahdin Hair Sheep.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Machine learning driven multi-omics analysis of the genetic mechanisms behind the double-coat fleece formation in Hetian sheep.Frontiers in genetics · 2025Article
- Genetic diversity of United States Rambouillet, Katahdin and Dorper sheep.Genetics, selection, evolution : GSE · 2024Article
- Ancient Sheep Genomes Reveal Four Millennia of North European Short-Tailed Sheep in the Baltic Sea Region.Genome biology and evolution · 2024Article
- Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep.Journal of advanced research · 2024Article
- Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability.Genetics, selection, evolution : GSE · 2024Article
- Whole-Genome Scanning for Selection Signatures Reveals Candidate Genes Associated with Growth and Tail Length in Sheep.Animals : an open access journal from MDPI · 2024Article
- Whole-Genome Resequencing Reveals Genetic Diversity and Wool Trait-Related Genes in Liangshan Semi-Fine-Wool Sheep.Animals : an open access journal from MDPI · 2024Article
- Whole genome sequencing identified genomic diversity and candidated genes associated with economic traits in Northeasern Merino in China.Frontiers in genetics · 2024Article
- Genomic signatures of selection, local adaptation and production type characterisation of East Adriatic sheep breeds.Journal of animal science and biotechnology · 2023Article
- Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep.Cell & bioscience · 2023Article
- Genome-wide DNA methylation and transcriptome analyses reveal the key gene for wool type variation in sheep.Journal of animal science and biotechnology · 2023Article
- A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes.Genome research · 2023Article
- Design and characterization of a high-resolution multiple-SNP capture array by target sequencing for sheep.Journal of animal science · 2023Article
- High-density SNP markers elucidate the genetic divergence and population structure of Noticiana sheep breed in the Mediterranean context.Frontiers in veterinary science · 2023Article
- Ovine HOXB13: expanding the gene repertoire of sheep tail patterning and implications in genetic improvement.Communications biology · 2022Article
- Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes.Genetics, selection, evolution : GSE · 2022Review
- Historical Westward Migration Phases ofGenes · 2022Article
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The composition and structure of fleece variation observed in mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece. Here, we report that the "woolly" allele results from the insertion of an antisense EIF2S2 retrogene (called asEIF2S2) into the 3' UTR of the IRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.
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