ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.JAMA network open · 2026Article
- Inverse association of insulin-like growth factor binding protein 1 with epicardial and intrathoracic adiposity in older adults: The Longenity study.Diabetes research and clinical practice · 2026Article
- GaitKeeper: An AI-Enabled Mobile Technology to Standardize and Measure Gait Speed.Sensors (Basel, Switzerland) · 2024Article
- Frailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study.International journal of environmental research and public health · 2023Observational
- Causal Associations between Paternal Longevity and Risks of Cardiovascular Diseases.Journal of cardiovascular development and disease · 2022Article
- Relative Trajectories of Gait and Cognitive Decline in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Trajectories of frailty in aging: Prospective cohort study.PloS one · 2021Article
- The relationship of parental longevity with the aging brain-results from UK Biobank.GeroScience · 2020Article
- Genetics of frailty: A longevity perspective.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Parental longevity predicts healthy ageing among women.Age and ageing · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAlthough many genetic and nongenetic factors interact to determine an individual's physical phenotype, there has been limited examination of the contribution of family history of exceptional parental longevity on decline in physical function in aging.
methodsThe LonGenity study recruited a relatively genetically homogenous cohort of Ashkenazi Jewish adults age 65 and older, who were defined as either offspring of parents with exceptional longevity ([OPEL]: having at least one parent who lived to age 95 or older) or offspring of parents with usual survival ([OPUS]: neither parent survived to age 95). Decline in performance on objective measures of strength (grip strength), balance (unipedal stance), and mobility (gait speed) as well as a composite physical function measure, the Short physical performance battery (SPPB), were compared between the two groups over a median follow-up of 3.2 years, accounting for age, sex, education, and comorbidities.
resultsOf the 984 LonGenity participants (mean age 76, 55% women), 448 were OPEL and 536 were OPUS. Compared to OPUS, OPEL had slower decline on measures of unipedal stance (-0.03 log-units/year, p = .026), repeated chair rise (0.13 s/year, p = .020) and SPPB (-0.11 points/year, p = .002). OPEL women had slower decline on chair rise and SPPB scores compared to OPUS women, although OPEL men had slower decline on unipedal stance compared to OPUS men.
conclusionOur findings provide evidence that variation in late-life decline in physical function is associated with familial longevity, and may vary for men and women.
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