ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Ebola Virus Disease and Pregnancy: A Retrospective Cohort Study of Patients Managed at 5 Ebola Treatment Units in West Africa.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Ebola virus disease in pregnancy: a systematic review and meta-analysis.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Pooled it
- Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola.Emerging infectious diseases · 2020Trial
- Viral threats to pregnancy: Global health risks in the era of pandemics.Advances in virus research · 2026Review
- Global Burden and Future Trends of Polycystic Ovary Syndrome: Insights from the GBD 2021 Study.International journal of women's health · 2025Article
- A premature newborn born to an adolescent girl with acute Ebola virus disease and malaria survives in a resource-limited setting in an Ebola treatment unit in DR Congo: "A case report".Clinical case reports · 2023Article
- Article
- RNA Viruses, Pregnancy and Vaccination: Emerging Lessons from COVID-19 and Ebola Virus Disease.Pathogens (Basel, Switzerland) · 2022Review
- The perinatal health challenges of emerging and re-emerging infectious diseases: A narrative review.Frontiers in public health · 2022Review
- Presence of Ebola virus in breast milk and risk of mother-to-child transmission: synthesis of evidence.Annals of the New York Academy of Sciences · 2021Review
- Scoping Review on the Impact of Outbreaks on Sexual and Reproductive Health Services: Proposed Frameworks for Pre-, Intra-, and Postoutbreak Situations.BioMed research international · 2021Article
- Atypical clinical presentation of Ebola virus disease in pregnancy: Implications for clinical and public health management.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Innate Immune Responses to Acute Viral Infection During Pregnancy.Frontiers in immunology · 2020Review
- One month follow up of a neonate born to a mother who survived Ebola virus disease during pregnancy: a case report in the Democratic Republic of Congo.BMC pediatrics · 2019Article
- Environmental temperature and case fatality of patients with Ebola virus disease in Sierra Leone and Liberia, 2014-2015: a retrospective cohort study.Tropical medicine & international health : TM & IH · 2019Article
- New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model.The Journal of infectious diseases · 2018Article
- Catching Chances: The Movement to Be on the Ground and Research Ready before an Outbreak.Viruses · 2018Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundReliable data are lacking on pregnancy outcomes during Ebola virus disease (EVD) epidemics. We aimed to characterize symptoms and outcomes among pregnant women admitted to Ebola treatment units (ETUs) with suspected and confirmed EVD to better inform obstetric management.
methodsWe analyzed a retrospective cohort of reproductive-aged women presenting to 5 West African ETUs from September 2014 to September 2015. We compared clinical symptoms, risk of EVD diagnosis, and mortality between pregnant and nonpregnant women.
resultsOf 729 reproductive-aged women admitted to study ETUs, 44 (6%) reported pregnancy. Thirteen of 44 pregnant women (30%) tested EVD positive; 6 of 13 (46%) died. Pregnant women were less likely than nonpregnant women to report anorexia, asthenia, diarrhea, fever, myalgias/arthralgias, nausea, or vomiting (P < .05) at admission. Pregnant women with suspected EVD had the same risk, however, of laboratory-confirmed EVD (30% vs 24%, P = .38). While pregnant women with confirmed EVD had similar Ebola viral loads on presentation to nonpregnant women, as measured by initial cycle threshold (26.4 vs 23.2, P = .16), they were less likely to have myalgias/arthralgias (P< .001) and vomiting (P = .02). Both all-cause mortality (14% vs 19%, P = .39) and EVD-specific mortality (46% vs 54%, P = .60) were not significantly different between pregnant and nonpregnant women. Two neonates born live in the ETU died within 8 days.
conclusionsWe find no evidence to support a difference in the risk of death between pregnant women with suspected or confirmed EVD compared to nonpregnant women. Limited data suggest poor fetal and neonatal outcomes in EVD-affected pregnancies.
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