ArticleGenome biology and evolution2017
Core Genes Evolve Rapidly in the Long-Term Evolution Experiment with Escherichia coli.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interaction between mutation type and gene pleiotropy drives parallel evolution in the laboratory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Pooled it
- Macrolide resistance trajectories across threeFrontiers in microbiology · 2026Article
- Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes.Evolution letters · 2025Article
- Adaptive laboratory evolution of Micrococcus luteus and identification of genes associated with radioresistance through genome-wide association study.Scientific reports · 2025Article
- Recent advances in genome-scale engineering inEngineering microbiology · 2024Review
- Changing fitness effects of mutations through long-term bacterial evolution.Science (New York, N.Y.) · 2024Article
- Article
- Growth-dependent Gene Expression Variation Influences the Strength of Codon Usage Biases.Molecular biology and evolution · 2023Article
- Growth-dependent gene expression variation influences the strength of codon usage biases.bioRxiv : the preprint server for biology · 2023Article
- Identifying Targets of Selection in Laboratory Evolution Experiments.Journal of molecular evolution · 2023Review
- Article
- Quantifying the local adaptive landscape of a nascent bacterial community.Nature communications · 2023Article
- Idiosyncratic Purifying Selection on Metabolic Enzymes in the Long-Term Evolution Experiment with Escherichia coli.Genome biology and evolution · 2022Article
- The landscape of transcriptional and translational changes over 22 years of bacterial adaptation.eLife · 2022Article
- Discovery of positive and purifying selection in metagenomic time series of hypermutator microbial populations.PLoS genetics · 2022Article
- Core genes can have higher recombination rates than accessory genes within global microbial populations.eLife · 2022Article
- Article
- Long-term experimental evolution decouples size and production costs inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution.Nature ecology & evolution · 2022Article
- Primordial mimicry induces morphological change in Escherichia coli.Communications biology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Bacteria can evolve rapidly under positive selection owing to their vast numbers, allowing their genes to diversify by adapting to different environments. We asked whether the same genes that evolve rapidly in the long-term evolution experiment (LTEE) with Escherichia coli have also diversified extensively in nature. To make this comparison, we identified ∼2000 core genes shared among 60 E. coli strains. During the LTEE, core genes accumulated significantly more nonsynonymous mutations than flexible (i.e., noncore) genes. Furthermore, core genes under positive selection in the LTEE are more conserved in nature than the average core gene. In some cases, adaptive mutations appear to modify protein functions, rather than merely knocking them out. The LTEE conditions are novel for E. coli, at least in relation to its evolutionary history in nature. The constancy and simplicity of the environment likely favor the complete loss of some unused functions and the fine-tuning of others.
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