Evidence map›Paper›PMID 28379355›Full record

ReviewChemical senses2017

Neuromodulation in Chemosensory Pathways.

Jeremy C McIntyre, Nicolas Thiebaud, John P McGann, Takaki Komiyama, Markus Rothermel

Abstract readReview
In one paragraph

Review in Chemical senses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. NIH Workshop Report: sensory nutrition and disease.The American journal of clinical nutrition · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Jeremy C McIntyreDepartment of Neuroscience and.
Nicolas ThiebaudDepartment of Biological Science and.
John P McGannBehavioral and Systems Neuroscience, Psychology Department, Rutgers University, New Brunswick, NJ, USA.
Takaki KomiyamaNeurobiology Section and Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA and.
Markus RothermelDepartment of Chemosensation, AG Neuromodulation, Institute for Biology II, RWTH Aachen University, Aachen 52074, Germany.
Florida State University · USRutgers, The State University of New Jersey · USRWTH Aachen University · DEUniversity of California, San Diego · USUniversity of Florida · US

Funding

How Fear Learning Alters Sensory Representations of Threat Predictive StimuliR01MH101293 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI MCGANN, JOHN P · 2013 to 2023
$4.5M
Sex differences in the neurophysiology of the olfactory systemR01DC013090 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI MCGANN, JOHN P · 2013 to 2017
$2.1M
Experience-driven plasticity of olfactory bulb odor representationsR01DC014690 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIYAMA, TAKAKI · 2015 to 2019
$1.9M
Glucagon-Like Peptide-1 (GLP-1) Signaling in the Olfactory SystemR03DC013988 · NIDCD · FLORIDA STATE UNIVERSITY · PI THIEBAUD, NICOLAS · 2016 to 2018
$446k
NIDCD NIH HHS R01 DC013090NIDCD NIH HHS R01 DC014690NIDCD NIH HHS R03 DC013988NIMH NIH HHS R01 MH101293
6 · The paper itself

Abstract

Interactions with the environment depend not only on sensory perception of external stimuli but also on processes of neuromodulation regulated by the internal state of an organism. These processes allow regulation of stimulus detection to match the demands of an organism influenced by its general brain state (satiety, wakefulness/sleep state, attentiveness, arousal, learning etc.). The sense of smell is initiated by sensory neurons located in the nasal cavity that recognize environmental odorants and project axons into the olfactory bulb (OB), where they form synapses with several types of neurons. Modulations of early synaptic circuits are particularly important since these can affect all subsequent processing steps. While the precise mechanisms have not been fully elucidated, work from many labs has demonstrated that the activity of neurons in the OB and cortex can be modulated by different factors inducing specific changes to olfactory information processing. The symposium "Neuromodulation in Chemosensory Pathways" at the International Symposium on Olfaction and Taste (ISOT 2016) highlighted some of the most recent advances in state-dependent network modulations of the mouse olfactory system including modulation mediated by specific neurotransmitters and neuroendocrine molecules, involving pharmacological, electrophysiological, learning, and behavioral approaches.

Indexed as

SmellAnimalsNeurotransmitter AgentsOlfactory BulbSensory Receptor CellsNeurotransmitter Agentshormonal statuslearningmouse olfactory systemnetwork modulationsstate-dependentsurprise and expectationtop–down inputs

Identifiers

PMID28379355
PMCPMC5863563
OpenAlexW2604585649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.