ReviewJournal of toxicology and environmental health. Part B, Critical reviews2017
Biomarkers of mercury toxicity: Past, present, and future trends.
Review in Journal of toxicology and environmental health. Part B, Critical reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04183595 (A Double-blinded, Randomized Controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of N1, N3-bis-), which is not on this map. Cited by 62 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double-blinded, Randomized Controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of N1, N3-bis-(2-Mercaptoethyl) Isophthalamide (NBMI) in the Reduction of Mercury Levels, in Subjects Exposed to Mercury in Colombia
Who cites it
62 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Clinical characteristics, management, and outcomes of diseases caused by mercury overexposure: a systematic review of case reports and case series.Frontiers in public health · 2026Pooled it
- Non-essential heavy metal effects in cardiovascular diseases: an overview of systematic reviews.Frontiers in cardiovascular medicine · 2024Pooled it
- Mercury and Prenatal Growth: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Mercury Exposure, Blood Pressure, and Hypertension: A Systematic Review and Dose-response Meta-analysis.Environmental health perspectives · 2018Pooled it
- Environmental contaminants and preeclampsia: a systematic literature review.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Pooled it
- The Protective Effects of Selenium Nanoparticles Against Metal Toxicity.Biological trace element research · 2026Review
- Human Mercury Biomonitoring Under the Minamata Convention: Blood, Urine, Hair, and Tissue Biomarkers (2000-2026).Biological trace element research · 2026Review
- Ellagic acid counteracts mercury chloride-induced oxidative stress and thiol oxidation in Drosophila melanogaster.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Article
- Tracing Toxicity: A Scientometric Perspective on Three Decades of Metallic Pollutants Research.Journal of toxicology · 2026Article
- Underexplored terrain: effects of high priority environmental toxicants on skeletal muscle.Journal of toxicology and environmental health. Part B, Critical reviews · 2026Review
- Exposure to toxic chemical elements (Pb, Cd, and Hg) and its association with sustained high blood pressure among secondary school attending adolescents in Northwestern Tanzania.Environmental research · 2025Article
- Concentrations of the serum long-chain omega-3 polyunsaturated fatty acids and hair mercury in men in different apolipoprotein E phenotypes.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Mercury toxicity resulting from enzyme alterations- minireview.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- Selective fluoride ion sensing using novel quinoline chemosensor insights into kinetics and molecular logic gate functions.Scientific reports · 2025Article
- Mercury exposure, epigenetic modifications, and genetic susceptibility: insights from molecular docking and population analysis.Frontiers in public health · 2025Article
- Interaction of mercury exposure and DNA methylation with sustained attention in children in a novel analysis of epigenetic susceptibility.Environmental epigenetics · 2025Article
- Environmental and genetic predictors of whole blood mercury and selenium concentrations in pregnant women in a UK birth cohort.Environmental advances · 2024Article
- Should ebselen be considered for the treatment of mercury intoxication? A minireview.Toxicology mechanisms and methods · 2024Review
- A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial compounds (methylmercury through fish, mercury vapor from dental amalgams, and ethylmercury from vaccines), the need for more sensitive and refined tools to assess the effects and/or susceptibility to adverse metal-mediated health risks remains. Traditional biomarkers, such as hair or blood Hg levels, are practical and provide a reliable measure of exposure, but given intra-population variability, it is difficult to establish accurate cause-effect relationships. It is therefore important to identify and validate biomarkers that are predictive of early adverse effects prior to adverse health outcomes becoming irreversible. This review describes the predominant biomarkers used by toxicologists and epidemiologists to evaluate exposure, effect and susceptibility to Hg compounds, weighing on their advantages and disadvantages. Most importantly, and in light of recent findings on the molecular mechanisms underlying Hg-mediated toxicity, potential novel biomarkers that might be predictive of toxic effect are presented, and the applicability of these parameters in risk assessment is examined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.