Evidence map›Paper›PMID 28379054›Full record

ArticleCell cycle (Georgetown, Tex.)2017

NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.

Shaoyan Feng, Guangwei Yang, Haidi Yang, Zibin Liang, Rongkai Zhang, Yunping Fan, Gehua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance.International journal of biological sciences · 2025
    Review
  3. Article
  4. E3 ubiquitin ligases in nasopharyngeal carcinoma and implications for therapies.Journal of molecular medicine (Berlin, Germany) · 2023
    Article
  5. Article
  6. Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Long noncoding RNA SMAD5-AS1 acts as a microRNA-106a-5p sponge to promote epithelial mesenchymal transition in nasopharyngeal carcinoma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shaoyan Fenga Department of Otorhinolaryngology, Head and Neck Surgery , The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.
Guangwei Yangc Department of Radiation Oncology , The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai , China.
Haidi Yangd Department of Otolaryngology , Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou , China.
Zibin Liangc Department of Radiation Oncology , The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai , China.
Rongkai Zhange Department of Orthopaedics , The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai , China.
Yunping Fanb Department of Otorhinolaryngology , Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai , China.
Gehua Zhanga Department of Otorhinolaryngology, Head and Neck Surgery , The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is a highly invasive head-neck cancer derived from the nasopharyngeal epithelium, mainly prevalent in southern China and Southeast Asia. Radiotherapy and adjuvant cisplatin (DDP) chemotherapy are standard administrations applied in the treatment of NPC. However, resistance to chemotherapeutic drugs has recently become more common, resulting in worse treatment outcome for NPC therapy. To elucidate the underlying molecular basis of drug resistance to DDP in NPC cells, we examined the morphocytology, cell motility and molecular changes in DDP-resistant NPC cells with respect to epithelial-mesenchymal transition (EMT) features. We found that EMT is closely associated with DDP-induced drug resistance in NPC cells, as DDP-resistant cells displayed morphological and molecular markers changes consistent with EMT. Wound healing and Transwell Boyden chamber assays revealed an enhanced migration and invasion potential in DDP-resistant NPC cells. Mechanistically, upregulation of NEDD4 was observed to relate to EMT in DDP-resistant cells. More importantly, depletion of NEDD4 in resistant cells led to a partial reversion of EMT phenotypes to MET characteristics. These data suggest that NEDD4 is largely involved in EMT features and chemoresistance of NPC cancer cells. NEDD4 could be a novel therapeutic target to overcome drug resistance in successful administrations of NPC.

Indexed as

Epithelial-Mesenchymal TransitionBiomarkers, TumorCarcinomaCell Line, TumorCell MovementCisplatinDown-RegulationDrug Resistance, NeoplasmHumansNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNedd4 Ubiquitin Protein LigasesNeoplasm InvasivenessRNA, MessengerBiomarkers, TumorCisplatinNedd4 protein, humanNedd4 Ubiquitin Protein LigasesRNA, Messengerdrug resistanceEMTNasopharyngeal carcinomaNEDD4

Identifiers

PMID28379054
PMCPMC5444352

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.