ArticleEuropean journal of clinical nutrition2017
Central adiposity-induced plasma-free amino acid alterations are associated with increased insulin resistance in healthy Singaporean adults.
Article in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- LC-MS/MS-based bioanalysis of branched-chain and aromatic amino acids in human serum.Bioanalysis · 2024Article
- A Review from a Clinical Perspective: Recent Advances in Biosensors for the Detection of L-Amino Acids.Biosensors · 2023Review
- Cross-sectional relationships between general and central adiposity and plasma amino acids in Chinese adults.Amino acids · 2023Article
- Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population.Nutrients · 2020Article
- Risk factors and impact of postoperative hyperglycemia in nondiabetic patients after cardiac surgery: A prospective study.Medicine · 2019Observational
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesRecent metabolomics technique reveals a plasma-free amino acid (PFAA)-based metabolite signature that is suggestive of altered PFAAs being an early manifestation of obesity-related insulin resistance. However, the PFAA profiles within non-obese, but more insulin-resistant Asians are not well researched. Compared with Caucasians, Asian populations have more central adiposity, which is generally regarded as metabolically more adverse, but the underlying mechanisms remain unclear. In the present study, we examined whether PFAA profiling was at least one important factor mediating central adiposity and insulin resistance, and aid in cardiovascular risk assessment in healthy Asians with normal body weight. SUBJECT/
methodsThis was a cross-sectional study. A total of 190 healthy men (n=87 with a mean±s.d. body mass index (BMI) of 23.5±3.5 kg/m
resultsSeven out of 18 amino acids were significantly correlated with measures of obesity (for example, waist circumference; waist-to-hip ratio and BMI) in current participants. Among them, the plasma concentrations of five amino acids, including Phe, Tyr, Met, Ala and His were positively associated with waist-to-hip ratio. With the exception of His, which had no association with insulin resistance, Phe, Tyr, Met and Ala were significantly associated with hyperinsulinemia and insulin resistance (P<0.05). In contrast, no associations were observed between circulating BCAAs (that is, Val, Leu, Ile), measures of obesity and insulin resistance. However, significant inverse associations were observed between BCAAs and total cholesterol and high-density lipoprotein.
conclusionsWe found that central adiposity was associated with alterations of specific amino acids. As a result, PFAAs may serve as metabolite predictors of hyperglycemia, hyperinsulinemia and dyslipidemia in healthy participants.
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