ArticleCancer medicine2017
A systematic investigation of the association between HPV and the clinicopathological parameters and prognosis of oral and oropharyngeal squamous cell carcinomas.
Article in Cancer medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Correlation Between Prognostic Indicators, HPV Status, and Cancer Stem Cell Markers in a Population of Human Tongue Carcinomas.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- The Role of Proinflammatory Biomarkers in Oral Cancer Pathophysiology.Advances in experimental medicine and biology · 2026Review
- Envisioning an Italian Head and Neck Proton Therapy Model-Based Selection: Challenge and Opportunity.International journal of particle therapy · 2025Article
- LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma.Scientific reports · 2024Article
- Ferroptosis and oral squamous cell carcinoma: connecting the dots to move forward.Frontiers in oral health · 2024Review
- The combined assessment of p16Frontiers in oncology · 2024Article
- Oral squamous cell carcinomas: state of the field and emerging directions.International journal of oral science · 2023Review
- Clinical analysis of 312 patients with stage IB1-IIA2 cervical squamous cell carcinoma and research on the influencing factors of postoperative recurrence.BMC women's health · 2023Article
- Analysis of T1-T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery.Laryngoscope investigative otolaryngology · 2023Article
- Human papillomavirus in oral squamous cell carcinoma using p16 and its co-relationship with cervical lymph node metastasis and clinicopathological parameters.Dental research journal · 2023Article
- Demographic Profile of p16 Immunopositive and HPV DNA PCR Positive Oral Squamous Cell Carcinoma in a Large Cohort of Indian Patients.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Comparison between three age-stratified cohorts reveals poor prognosis of young patients with tongue carcinoma.Frontiers in oncology · 2022Article
- Oral Microbial Species and Virulence Factors Associated with Oral Squamous Cell Carcinoma.Microbial ecology · 2021Article
- Epithelial-Mesenchymal Transition Predicts Survival in Oral Squamous Cell Carcinoma.Pathology oncology research : POR · 2020Article
- The Clinical Relevance of p16 and p53 Status in Patients with Squamous Cell Carcinoma of the Vulva.Journal of oncology · 2020Article
- Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples.Oral oncology · 2020Article
- Article
- Significance of the neutrophil-to-lymphocyte ratio in young patients with oral squamous cell carcinoma.Cancer management and research · 2019Article
- Incidence, mortality, and temporal patterns of oropharyngeal cancer in China: a population-based study.Cancer communications (London, England) · 2018Article
- Nomograms forecasting long-term overall and cancer-specific survival of patients with oral squamous cell carcinoma.Cancer medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus (HPV), the causal factor of cervical cancers, was closely linked to the etiology and prognosis of oropharyngeal squamous cell carcinoma (OPSCC), but its role in oral squamous cell carcinoma (OSCC) was unclear. In addition, few researches based on Chinese population were documented. Hence, we sought to investigate the relationship of HPV marker P16 protein to the clinicopathological parameters and survival of OPSCC and OSCC patients systematically to assess the influence of ethnic, regional difference on HPV susceptibility. Specimens from 93 OPSCC patients and 95 OSCC patients were recut, and P16 immunohistochemistry (IHC) was performed. Moreover, survival analysis was conducted to confirm the independent factors that influenced the prognosis. The P16 results were positive in 25.8% and 9.5% of patients with OPSCC and OSCC, respectively. The overall survival (OS) of HPV-positive OPSCC patients was significantly longer than that of HPV-negative OPSCC patients (P = 0.004). Conversely, statistical significance was not observed regarding the OS of OSCC patients (P = 0.343). Cox regression analysis indicated that T stage and P16 status were independent factors that affected the prognosis of OPSCC patients, and the smoking index influenced the prognosis of OSCC patients. Among OPSCC patients who received radiochemotherapy (RCT), HPV-positive patients had a better survival rate than their HPV-negative counterparts (P = 0.015). Conversely, no significant difference was observed between HPV-positive and HPV-negative OSCC patients who received RCT (P = 0.237). P16 is a credible surrogate by which to define HPV status. HPV expression had a favorable effect on OPSCC patients as opposed to their OSCC counterparts in this single center population-based study.
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