ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017
Prolonged suppressive antibiotic therapy for prosthetic joint infection in the elderly: a national multicentre cohort study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Bacteriophage therapy as an innovative strategy for the treatment of Periprosthetic Joint Infection: a systematic review.International orthopaedics · 2024Pooled it
- Diagnosis and treatment of mycoplasmal septic arthritis: a systematic review.International orthopaedics · 2020Pooled it
- Outcome of guided persistent fistula as a salvage procedure in patients with chronic periprosthetic joint infection.International orthopaedics · 2026Observational
- Adverse events and tolerability of long-term suppressive antibiotic therapy for periprosthetic joint infection: a prospective cohort study.Journal of bone and joint infection · 2026Article
- Outcomes of Long-Term Antibiotic Therapy for Prosthetic Joint Infection: A Cohort Study in a Canadian High-Volume Arthroplasty Center.Arthroplasty today · 2025Article
- Bacteriophage therapy created the necessary conditions for successful antibiotic suppression in a periprosthetic hip joint infection: a Case Report.Frontiers in medicine · 2025Article
- The Use of Long-term Antibiotics for Suppression of Bacterial Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Review
- Review
- Phage therapy in prosthetic joint infections caused by Staphylococcus aureus - A literature review.European journal of microbiology & immunology · 2024Review
- Dosing and treatment duration of suppressive antimicrobial therapy in orthopedic implant infections: a cohort study.Journal of bone and joint infection · 2024Article
- Adverse Events Associated with Prolonged Antibiotic Therapy for Periprosthetic Joint Infections-A Prospective Study with a Special Focus on Rifampin.Antibiotics (Basel, Switzerland) · 2023Article
- Periprosthetic Joint Infection: Current Clinical Challenges.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Knee Arthrodesis: An Analysis of Surgical Risk Factors and Complications Using a National Database.Arthroplasty today · 2023Article
- Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety.Frontiers in pharmacology · 2023Article
- Outcomes of Second-stage Reimplantation After Modular Knee Arthrodesis for Periprosthetic Joint Infection.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Article
- Local antibiotic treatment with calcium sulfate as carrier material improves the outcome of debridement, antibiotics, and implant retention procedures for periprosthetic joint infections after hip arthroplasty - a retrospective study.Journal of bone and joint infection · 2022Article
- Asymptomatic Periprosthetic Joint Infection of the Hip with High-Virulence Pathogens: Report of Two Cases.Case reports in infectious diseases · 2022Article
- Safety of Tedizolid as Suppressive Antimicrobial Therapy for Patients With Complex Implant-Associated Bone and Joint Infection due to Multidrug-Resistant Gram-Positive Pathogens: Results From the TediSAT Cohort Study.Open forum infectious diseases · 2021Article
- Osteoarticular infections: a specific program for older patients?Aging clinical and experimental research · 2021Review
Corrections and comments
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Authors and funding
48 authors at 20 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During prosthetic joint infection (PJI), optimal surgical management with exchange of the device is sometimes impossible, especially in the elderly population. Thus, prolonged suppressive antibiotic therapy (PSAT) is the only option to prevent acute sepsis, but little is known about this strategy. We aimed to describe the characteristics, outcome and tolerance of PSAT in elderly patients with PJI. We performed a national cross-sectional cohort study of patients >75 years old and treated with PSAT for PJI. We evaluated the occurrence of events, which were defined as: (i) local or systemic progression of the infection (failure), (ii) death and (iii) discontinuation or switch of PSAT. A total of 136 patients were included, with a median age of 83 years [interquartile range (IQR) 81-88]. The predominant pathogen involved was Staphylococcus (62.1%) (Staphylococcus aureus in 41.7%). A single antimicrobial drug was prescribed in 96 cases (70.6%). There were 46 (33.8%) patients with an event: 25 (18%) with an adverse drug reaction leading to definitive discontinuation or switch of PSAT, 8 (5.9%) with progression of sepsis and 13 died (9.6%). Among patients under follow-up, the survival rate without an event at 2 years was 61% [95% confidence interval (CI): 51;74]. In the multivariate Cox analysis, patients with higher World Health Organization (WHO) score had an increased risk of an event [hazard ratio (HR) = 1.5, p = 0.014], whereas patients treated with beta-lactams are associated with less risk of events occurring (HR = 0.5, p = 0.048). In our cohort, PSAT could be an effective and safe option for PJI in the elderly.
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