Evidence map›Paper›PMID 28378198›Full record

ArticleJournal of natural medicines2017

Sharkquinone, a new ana-quinonoid tetracene derivative from marine-derived Streptomyces sp. EGY1 with TRAIL resistance-overcoming activity.

Mohamed S Abdelfattah, Mohammed I Y Elmallah, Adal A Mohamed, Masami Ishibashi

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Article in Journal of natural medicines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Mohamed S AbdelfattahMarine Natural Products Unit (MNPRU), Faculty of Science, Helwan University, Ain Helwan, Cairo, 11795, Egypt. mabdelfattah@science.helwan.edu.eg.
Mohammed I Y ElmallahMarine Natural Products Unit (MNPRU), Faculty of Science, Helwan University, Ain Helwan, Cairo, 11795, Egypt.
Adal A MohamedChemistry Department, Faculty of Science, Helwan University, Ain Helwan, Cairo, 11795, Egypt.
Masami IshibashiGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Helwan University · EGChiba University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new ana-quinonoid tetracene metabolite, named sharkquinone (1), and the known SS-228R (2) have been isolated from the ethyl acetate extract of the culture of marine Streptomyces sp. EGY1. The strain was isolated from sediment sample collected from the Red Sea coast of Egypt. The structure of sharkquinone (1) was elucidated using detailed spectral (HRESI-MS, 1D and 2D NMR) analyses and quantum chemical calculations. This is the first report of the isolation of ana-quinonoid tetracene derivative from a natural source. Compound 1 showed the ability to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance at a concentration of 10 μM in human gastric adenocarcinoma (AGS) cells.

Indexed as

AdenocarcinomaBiological ProductsQuinonesStomach NeoplasmsStreptomycesTNF-Related Apoptosis-Inducing LigandAquatic OrganismsCell Line, TumorEgyptHumansMagnetic Resonance SpectroscopyMolecular StructureNaphthacenesBiological ProductsnaphthaceneNaphthacenesQuinonessharkquinoneTNF-Related Apoptosis-Inducing LigandActinomycetesana-QuinonoidSpectroscopyTRAIL

Identifiers

PMID28378198
OpenAlexW2604506697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.