ArticleMolecular and cellular biochemistry2017
Balsamin induces apoptosis in breast cancer cells via DNA fragmentation and cell cycle arrest.
Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- ProbioticJournal of microbiology and biotechnology · 2026Article
- Trachystemon orientalis (L.) G. Don aqueous extract induces cell cycle arrest and apoptosis in MCF-7 breast cancer cells via multi-pathway modulation.BMC complementary medicine and therapies · 2026Article
- Biodiversity Conservation, a Crucial Step Towards Food and Nutritional Security, Food Justice and Climate Change Resilience in Africa.Plants (Basel, Switzerland) · 2025Article
- The Impact of Light Wavelength and Darkness on Metabolite Profiling of Korean Ginseng: Evaluating Its Anti-Cancer Potential against MCF-7 and BV-2 Cell Lines.International journal of molecular sciences · 2023Article
- The inhibitory effect and mechanism of Resina Draconis on the proliferation of MCF-7 breast cancer cells: a network pharmacology-based analysis.Scientific reports · 2023Article
- High-qualityFrontiers in plant science · 2023Article
- Structural Distinctive 26SK, a Ribosome-Inactivating Protein from Jatropha curcas and Its Biological Activities.Applied biochemistry and biotechnology · 2021Article
- Bioactive peptide of3 Biotech · 2021Article
- Oxymatrine inhibits proliferation and apoptosis of human breast cancer cells through the regulation of miRNA-140-5P.American journal of translational research · 2021Article
- Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans.Bioscience reports · 2020Article
- Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells.Frontiers in pharmacology · 2020Article
- Identification of Hub Genes Using Co-Expression Network Analysis in Breast Cancer as a Tool to Predict Different Stages.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation.Nanoscale research letters · 2019Article
- Apoptotic role of marine sponge symbiont Bacillus subtilis NMK17 through the activation of caspase-3 in human breast cancer cell line.Molecular biology reports · 2018Article
- An overview of apoptosis assays detecting DNA fragmentation.Molecular biology reports · 2018Review
- A Synthetic Peptide AWRK6 Alleviates Lipopolysaccharide-Induced Liver Injury.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the second most common cancer causing death worldwide with metastasis and disease relapse being the major drawbacks in current treatments. Therefore, development of novel drugs is needed. Balsamin, a 28 kDa Type I ribosome-inactivating protein, is rich in the seeds of Momordica balsamina. In this study, the molecular mechanism and the possible effects of balsamin on the two key hallmarks of cancer were investigated. Firstly, the induction of apoptosis in human breast cancer MCF-7 and BT549 cells showed that balsamin-induced apoptosis involved increases in caspase-3 and caspase-8 activity, upregulation of Bax, Bid, and Bad, and downregulation of BCL-2 and BCL-XL. Furthermore, balsamin inhibited the proliferation of breast cancer cells in a dose-dependent manner with IC
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