Evidence map›Paper›PMID 28378118›Full record

ArticleImmunologic research2017

miR-451 limits CD4

Lesley M Chapman, Sara K Ture, David J Field, Craig N Morrell

Open access · greenAbstract read
In one paragraph

Article in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. miR-144/451: A Regulatory Role in Inflammation.Current molecular medicine · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Expression Analysis ofInternational journal of molecular sciences · 2022
    Article
  11. MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection.International journal of environmental research and public health · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Role of Cytokines in Experimental and Human Visceral Leishmaniasis.Frontiers in cellular and infection microbiology · 2021
    Review
  16. Article
  17. Article
  18. Transcriptional Regulation of gga-miR-451 by AhR:Arnt inInternational journal of molecular sciences · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lesley M ChapmanAab Cardiovascular Research Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA.
Sara K TureAab Cardiovascular Research Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA.
David J FieldAab Cardiovascular Research Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA.
Craig N MorrellAab Cardiovascular Research Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA. Craig_Morrell@urmc.rochester.edu.
University of Rochester Medical Center · USSouthern California Clinical and Translational Science Institute · US

Funding

UNIVERSITY OF ROCHESTER'S RESEARCH ASSOCIATE ORGANIZATIONUL1RR024160 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$38.7M
The University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4M
The University of Rochester's Clinical and Translational Science InstituteTL1RR024135 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$3.7M
Novel platelet functions for in T-cell helper cell responsesR01HL124018 · NHLBI · UNIVERSITY OF ROCHESTER · PI MORRELL, CRAIG N · 2015 to 2018
$1.5M
The University of Rochester Clinical and Translational Science InstituteTL1TR000096 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$930k
VAMP8 regulates endothelial exocytosis and microvascular obstructionR56HL124042 · NHLBI · UNIVERSITY OF ROCHESTER · PI LOWENSTEIN, CHARLES J, MORRELL, CRAIG N · 2014 to 2014
$384k
Mechanisms of microRNA-451 mediated regulation of malaria infection in miceF31AI108187 · NIAID · UNIVERSITY OF ROCHESTER · PI CHAPMAN, LESLEY M · 2014 to 2014
$43k
NCATS NIH HHS TL1 TR000096NCATS NIH HHS UL1 TR000042NCRR NIH HHS TL1 RR024135NCRR NIH HHS UL1 RR024160NHLBI NIH HHS R01 HL124018NHLBI NIH HHS R56 HL124042NIAID NIH HHS F31 AI108187
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are major regulators of cell responses, particularly in stressed cell states and host immune responses. Some miRNAs have a role in pathogen defense, including regulation of immune responses to Plasmodium parasite infection. Using a nonlethal mouse model of blood stage malaria infection, we have found that miR-451

Indexed as

AnimalsCD4-Positive T-LymphocytesCell CycleCell ProliferationCells, CulturedHumansLymphocyte ActivationMalariaMiceMice, Inbred C57BLMice, KnockoutMicroRNAsPlasmodium yoeliiProto-Oncogene Proteins c-mycUp-RegulationMicroRNAsMirn451 microRNA, mouseMyc protein, mouseProto-Oncogene Proteins c-mycMalariamiRNAmycProliferationT cell

Identifiers

PMID28378118
PMCPMC5545071
OpenAlexW2605274138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.