Evidence map›Paper›PMID 28378033›Full record

ArticleDiabetologia2017

Independent associations between a metabolic syndrome severity score and future diabetes by sex and race: the Atherosclerosis Risk In Communities Study and Jackson Heart Study.

Matthew J Gurka, Sherita H Golden, Solomon K Musani, Mario Sims, Abhishek Vishnu, Yi Guo, Michelle Cardel, Thomas A Pearson, Mark D DeBoer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 105 citations in OpenAlex.

  1. Impact of Setmelanotide on Metabolic Syndrome Risk in Patients With Bardet-Biedl Syndrome.The Journal of clinical endocrinology and metabolism · 2025
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  20. Galectin-3, Metabolic Risk, and Incident Heart Failure: The ARIC Study.Journal of the American Heart Association · 2024
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Matthew J GurkaDepartment of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville, FL, USA.
Sherita H GoldenDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Solomon K MusaniDepartment of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Mario SimsDepartment of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Abhishek VishnuDepartment of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville, FL, USA.
Yi GuoDepartment of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville, FL, USA.
Michelle CardelDepartment of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville, FL, USA.
Thomas A PearsonDepartment of Epidemiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Mark D DeBoerDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Virginia, 409 Lane Road, Room 2017, PO Box 800386, Charlottesville, VA, 22908, USA. deboer@virginia.edu.
University of Florida · USJackson Memorial Hospital · USJohns Hopkins University · USUniversity of Virginia · US

Funding

Socioeconomic Status and Subjective Social Status as Modifiers of Stressors and Discrimination in their Relationship with MetS Severity Over TimeR01HL120960 · NHLBI · WEST VIRGINIA UNIVERSITY · PI DEBOER, MARK DANIEL, GURKA, MATTHEW JAMES · 2014 to 2018
$2.1M
NHLBI NIH HHS HHSN268201000010CNHLBI NIH HHS HHSN268201000011CNHLBI NIH HHS HHSN268201000012CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS R01 HL120960
6 · The paper itself

Abstract

aims/hypothesisThe study aimed to assess for an association between the degree of severity of the metabolic syndrome and risk of type 2 diabetes beyond that conferred by the individual components of the metabolic syndrome.

methodsWe assessed HRs for an Adult Treatment Panel III (ATP-III) metabolic syndrome score (ATP-III MetS) and a sex- and race-specific continuous metabolic syndrome severity z score related to incident diabetes over a median of 7.8 years of follow-up among participants of two observational cohorts, the Atherosclerosis Risk in Communities study (n = 10,957) and the Jackson Heart Study (n = 2137).

resultsThe ATP-III MetS had an HR for incident diabetes of 4.36 (95% CI 3.83, 4.97), which was attenuated in models that included the individual metabolic syndrome components. By contrast, participants in the fourth quartile of metabolic syndrome severity (compared with the first quartile) had an HR of 17.4 (95% CI 12.6, 24.1) for future diabetes; in models that also included the individual metabolic syndrome components, this remained significant, with an HR of 3.69 (95% CI 2.42, 5.64). There was a race × metabolic syndrome interaction in these models such that HR was greater for black participants (5.30) than white participants (2.24). When the change in metabolic syndrome severity score was included in the hazard models, this conferred a further association, with changes in metabolic syndrome severity score of ≥0.5 having a HR of 2.66 compared with changes in metabolic syndrome severity score of ≤0. CONCLUSIONS/

interpretationUse of a continuous sex- and race-specific metabolic syndrome severity z score provided an additional prediction of risk of diabetes beyond that of the individual metabolic syndrome components, suggesting an added risk conferred by the processes underlying the metabolic syndrome. Increases in this score over time were associated with further risk, supporting the potential clinical utility of following metabolic syndrome severity over time.

Indexed as

AdultAgedAged, 80 and overAtherosclerosisBody Mass IndexDiabetes Mellitus, Type 2EthnicityFemaleFollow-Up StudiesHumansInsulin ResistanceKaplan-Meier EstimateMaleMetabolic SyndromeMiddle AgedModels, StatisticalInsulin resistanceMetabolic syndromeRiskType 2 diabetes mellitus

Identifiers

PMID28378033
PMCPMC5481783
OpenAlexW2605228899

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.