ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017
δ scores predict mild cognitive impairment and Alzheimer's disease conversions from nondemented states.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial.Translational neurodegeneration · 2023Trial
- Biomarker affliction classes contribute additively to observed dementia severity and prospective conversion risk.Journal of Alzheimer's disease : JAD · 2026Article
- Statin use moderates APOE's and CRP's associations with dementia and is associated with lesser dementia severity in ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neuropsychological assessment of mild cognitive impairment in Latinx adults: A scoping review.Neuropsychology · 2020Article
- Blood-based protein predictors of dementia severity as measured by δ: Replication across biofluids and cohorts.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionWe tested the latent variable "δ" (for "dementia")'s ability to predict conversion to "mild cognitive impairment" (MCI) and Alzheimer's disease (AD).
methodsAn ethnicity equivalent d homolog ("dEQ") was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. "Normal Controls" (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4.7(0.6)].
results22.0% (n = 281) of NC converted to "MCI" or "AD". 17.3%( n = 106) of MCI converted to "AD." Independently of covariates, each quintile increase in the dEQ scores of NC increased the odds of conversion by 52%. Each quintile increase in the dEQ scores of MCI cases increased the odds of conversion to AD almost three-fold. DISCUSSION: Baseline δ scores predict MCI and AD conversions from nondemented states in MA and NHW.
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