ArticleNeurobiology of stress2017
The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by
Article in Neurobiology of stress, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lifetime posttraumatic stress disorder as a predictor of mortality: a systematic review and meta-analysis.BMC psychiatry · 2023Pooled it
- The Association of Periodontal Status, Salivary Flow Rate, Salivary Cortisol Levels, and Cytokine Levels with Cognitive Status in Elderly Subjects.Geriatrics (Basel, Switzerland) · 2025Article
- [Influences of Autonomic Function, Salivary Cortisol and Physical Activity on Cognitive Functions in Institutionalized Older Adults with Mild Cognitive Impairment: Based on Neurovisceral Integration Model].Journal of Korean Academy of Nursing · 2021Article
- 11β-Hydroxylase (CYP11B1) gene variants and new-onset depression in later life.Journal of psychiatry & neuroscience : JPN · 2021Article
- Risk and protective effects of serotonin and BDNF genes on stress-related adult psychiatric symptoms.Neurobiology of stress · 2019Article
- Examining HPA-axis functioning as a mediator of the relationship between depression and cognition across the adult lifespan.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2019Article
- 5-HTTLPR × stress hypothesis: is the debate over?Molecular psychiatry · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn adverse psychological environment (e.g. stressful events or depression) has been shown to influence basal cortisol levels and cortisol response to stress. This differs depending on the adverse stimuli, but also varies across individuals and may be influenced by genetic predisposition. An insertion/deletion polymorphism in the serotonin transporter gene (
objectiveTo investigate how stressful life events and depression are associated with diurnal cortisol levels in community-dwelling elderly and determine whether this varies according to genetic variability in the
methodsThis population-based study included 334 subjects aged 65 and older (mean (SD) = 76.5 (6.3)). Diurnal cortisol was measured on two separate days, under quiet (basal) and stressful conditions. The number of recent major stressful events experienced during the past year was assessed from a 12-item validated questionnaire as an index of cumulative recent stressful events. Lifetime trauma was evaluated using the validated Watson's PTSD inventory, which evaluates the most severe traumatic or frightening experience according to DSM criteria. Depression was defined as having a Mini-International Neuropsychiatric Interview (MINI) diagnosis of current major depressive disorder or high levels of depressive symptoms (Center for Epidemiologic Studies-Depression Scale ≥16).
resultsExposure to stressful life events was associated with lower basal evening cortisol levels overall, and in the participants with the
conclusionAn adverse psychological environment is associated with basal cortisol levels and cortisol stress response, but this differs according to
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