Evidence map›Paper›PMID 28377971›Full record

ArticleBone reports2015

Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement.

Ju-Young Kim, Myeung Su Lee, Jong Min Baek, Jongtae Park, Byung-Soo Youn, Jaemin Oh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Lipopolysaccharide-Induced Bone Loss in Rodent Models: A Systematic Review and Meta-Analysis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Pooled it
  2. Article
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  7. Current issues in molecular biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ju-Young KimImaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Myeung Su LeeImaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Jong Min BaekDepartment of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Jongtae ParkDepartment of Neurosurgery, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Byung-Soo YounBiomedical Research Center, University of Ulsan College of Medicine, Ulsan University Hospital, 877 Bangeojinsunwhando-ro, Dong-Ku, Ulsan 682-714, Republic of Korea; OsteoNeuroGen 40 MiKeum-ro, Bundang, Kyunggi 461-871, Republic of Korea.
Jaemin OhImaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Wonkwang University · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is an aging-associated disease requiring better therapeutic modality. Eupatilin is a major flavonoid from

Indexed as

Actin depolymerization;ALP, alkaline phosphataseBMCs, bone marrow cellsBMMs, bone marrow macrophagesCytoskeletal rearrangementFBS, fetal bovine serumHDACis, Histone deacetylase inhibitorsH&E, hematoxylin and eosinLPS, lipopolysaccharideM-CSF, macrophage colony-stimulating factorMNCs, multinucleated cellsNFATc1, nuclear factor of activated T cells c1OB, osteoblastsOC, osteoclastsOsteoclastogenesis;OVX, ovariectomizedPGE2, prostaglandin E2RANKL, RANK ligandRANK, the receptor activator of nuclear factor κBSD, standard deviationSE, standard errorSOST, sclerostinTBST, tris-buffered saline contacting 0.1% Tween-20Transcriptional repression;TRAP, tartrate-resistant acid phosphateXTT, sodium3’-[1-(phenyl-aminocarbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)α-MEM, α-minimum essential mediumμCT, micro-computed tomography

Identifiers

PMID28377971
PMCPMC5365243
OpenAlexW2184978838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.