ArticleBone reports2015
The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue.
Article in Bone reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lipopolysaccharide-Induced Bone Loss in Rodent Models: A Systematic Review and Meta-Analysis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Pooled it
- A Gyroid TPMS-based machine learning framework for rapid prediction of cancellous bone mechanical properties.Frontiers in bioengineering and biotechnology · 2026Article
- Xolography for Biomedical Applications: Dual-Color Light-Sheet Printing of Hydrogels With Local Control Over Shape and Stiffness.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Fracture toughness of cancellous iliac bone.Open veterinary journal · 2024Article
- A Controlled Variable Study of the Biomechanical Properties of the Proximal Femur before and after Cancellous Bone Removal.Orthopaedic surgery · 2024Article
- Predicting the Fracture Toughness of Human Cancellous Bone in Fractured Neck of Femur Patients Using Bone Volume and Micro-Architecture.Life (Basel, Switzerland) · 2024Article
- Sex-specific effects ofJBMR plus · 2024Article
- Long Bone Mineral Loss, Bone Microstructural Changes and Oxidative Stress AfterFrontiers in physiology · 2022Article
- The Correlation of Regional Microstructure and Mechanics of the Cervical Articular Process in Adults.Materials (Basel, Switzerland) · 2021Article
- Increased Potential of Bone Formation with the Intravenous Injection of a Parathyroid Hormone-Related Protein Minicircle DNA Vector.International journal of molecular sciences · 2021Article
- Characterization of Ultralow Density Cellular Solids: Lessons from 30 years of Bone Biomechanics Research.Advanced engineering materials · 2021Article
- Prediction of trabecular bone architectural features by deep learning models using simulated DXA images.Bone reports · 2020Article
- Influence of thermodisinfection on microstructure of human femoral heads: duration of heat exposition and compressive strength.Cell and tissue banking · 2020Article
- Effects of treadmill with different intensities on bone quality and muscle properties in adult rats.Biomedical engineering online · 2019Article
- Age-Related Changes in Femoral Head Trabecular Microarchitecture.Aging and disease · 2018Article
- Bone Research Society, Annual Meeting 2017 Proceedings. 25-27 June 2017, Bristol, UK.Journal of musculoskeletal & neuronal interactions · 2018Article
- The effect of long-term bisphosphonate therapy on trabecular bone strength and microcrack density.Bone & joint research · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is clinically assessed from bone mineral density measurements using dual energy X-ray absorption (DXA). However, these measurements do not always provide an accurate fracture prediction, arguably because DXA does not grapple with 'bone quality', which is a combined result of microarchitecture, texture, bone tissue properties, past loading history, material chemistry and bone physiology in reaction to disease. Studies addressing bone quality are comparatively few if one considers the potential importance of this factor. They suffer due to low number of human osteoporotic specimens, use of animal proxies and/or the lack of differentiation between confounding parameters such as gender and state of diseased bone. The present study considers bone samples donated from patients (n = 37) who suffered a femoral neck fracture and in this very well defined cohort we have produced in previous work fracture toughness measurements (FT) which quantify its ability to resist crack growth which reflects directly the structural integrity of the cancellous bone tissue. We investigated correlations between BV/TV and other microarchitectural parameters; we examined effects that may suggest differences in bone remodelling between males and females and compared the relationships with the FT properties. The data crucially has shown that TbTh, TbSp, SMI and TbN may provide a proxy or surrogate for BV/TV. Correlations between FT critical stress intensity values and microarchitecture parameters (BV/TV, BS/TV, TbN, BS/BV and SMI) for osteoporotic cancellous tissue were observed and are for the first time reported in this study. Overall, this study has not only highlighted that the fracture model based upon BMD could potentially be improved with inclusion of other microarchitecture parameters, but has also given us clear clues as to which of them are more influential in this role.
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