ArticleBone reports2015
Management of hypoparathyroidism in pregnancy and lactation - A report of 10 cases.
Article in Bone reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Clinical and genetic insights into Autosomal Dominant Hypocalcemia type 1: a single-center case series including genotype-phenotype correlations, pregnancy outcomes, and novel CASR variants.Journal of endocrinological investigation · 2026Article
- Management of Chronic Hypoparathyroidism and Hyperparathyroidism in Pregnancy/Lactation.Current osteoporosis reports · 2026Review
- Severe Hypercalcemia During Lactation in a Patient With Pre-existing Hypoparathyroidism.Cureus · 2026Article
- Association of Serum Magnesium and Calcium Levels in Patients with and without Diastolic Notch in Uterine Artery Doppler Ultrasonography Imaging in the Second Trimester.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Does Lactation Predispose to Severe Hypocalcemia Post Total Thyroidectomy? A Case Series.Indian journal of surgical oncology · 2025Article
- Article
- Use of rhPTH(1-84) for hypoparathyroidism during early pregnancy and lactation.Endocrinology, diabetes & metabolism case reports · 2023Article
- Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: A Systematic Current Practice Survey.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Subcutaneous Infusion of rhPTHJournal of the Endocrine Society · 2022Article
- European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders.European journal of endocrinology · 2022Article
- Hypoparathyroidism and pseudohypoparathyroidism in pregnancy: an Italian retrospective observational study.Orphanet journal of rare diseases · 2021Observational
- Parathyroid Disease in Pregnancy and Lactation: A Narrative Review of the Literature.Biomedicines · 2021Review
- Hypoparathyroidism in Pregnancy and Lactation: Current Approach to Diagnosis and Management.Journal of clinical medicine · 2021Review
- Lip Tremor in Hypocalcemia.Journal of neurosciences in rural practice · 2020Article
- Standards of care for hypoparathyroidism in adults: a Canadian and International Consensus.European journal of endocrinology · 2019Review
- Hypocalcemia in Pregnancy: A Clinical Review Update.Oman medical journal · 2018Article
- Idiopathic Hypoparathyroidism and Severe Hypocalcemia in Pregnancy.Case reports in endocrinology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypoparathyroidism in pregnancy is rare, but important, as it is associated with maternal morbidity and foetal loss. There are limited case reports and no established management guidelines. Optimal maintenance of calcium levels during pregnancy is required to minimise the risk of related complications. This study aims to identify causes and examine outcomes of hypoparathyroidism in pregnancy in a cohort of women delivering at a large referral centre. DESIGN AND
methodThe Monash Health maternity service database captures pregnancy and birthing outcomes in over 9000 women each year. We audited this database between 2000 and 2014 to examine the clinical course, treatment and outcomes of pregnant women with hypoparathyroidism.
resultsWe identified 10 pregnancies from 6 women with pre-existing hypoparathyroidism secondary to idiopathic hypoparathyroidism (n = 3), autosomal dominant branchial arch disorder with hypoparathyroidism (n = 3) and autosomal dominant hypocalcaemia (n = 1), surgery for thyroid cancer (n = 2) and Graves' disease (n = 1). Maternal calcium levels were monitored through pregnancy and management adjusted to maintain normocalcaemia. One woman was delivered by caesarean section at 34 weeks' gestation because of intrauterine growth restriction, and oligohydramnios complicated two other pregnancies. The postpartum period was complicated by severe hypercalcaemia in one woman and by symptomatic, labile serum calcium levels during lactation in another woman, requiring close monitoring over a 6 month period.
conclusionAlthough rare, hypoparathyroidism in pregnancy poses a management challenge for clinicians, and co-ordinated care is required by obstetricians and endocrinologists to ensure optimal outcomes for both mother and baby. Continued monitoring of maternal calcium levels during lactation and weaning is essential to avoid the potential complications of either hypercalcaemia or hypocalcaemia.
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