Evidence map›Paper›PMID 28377876›Full record

ArticleMolecular metabolism2017

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus.

Yury M Morozov, Marco Koch, Pasko Rakic, Tamas L Horvath

Open access · goldAbstract read
In one paragraph

Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

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  13. Hypothalamic endocannabinoids in obesity: an old story with new challenges.Cellular and molecular life sciences : CMLS · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Yury M MorozovDepartment of Neuroscience, Yale University School of Medicine, 06520 New Haven, CT, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, 06520 New Haven, CT, USA. Electronic address: yury.morozov@yale.edu.
Marco KochProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, 06520 New Haven, CT, USA; Institute of Anatomy, University of Leipzig, 04103 Leipzig, Germany.
Pasko RakicDepartment of Neuroscience, Yale University School of Medicine, 06520 New Haven, CT, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, 06520 New Haven, CT, USA.
Tamas L HorvathProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, 06520 New Haven, CT, USA. Electronic address: tamas.horvath@yale.edu.
Yale University · US

Funding

The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7M
Origin of Cortical Species-specific Distinctions.R01DA023999 · NIDA · YALE UNIVERSITY · PI RAKIC, PASKO · 2008 to 2019
$7.9M
PRENATAL DEVELOPMENT OF THE VISUAL SYSTEMR01EY002593 · NEI · YALE UNIVERSITY · PI ARELLANO, JUAN I, RAKIC, PASKO · 1985 to 2018
$6.5M
Origin of Cortical Species-specific DistinctionsR37DA023999 · NIDA · YALE UNIVERSITY · PI PASKO RAKIC · 2020 to 2026
$5.6M
Feeding Driven by POMC NeuronsR01DK111178 · NIDDK · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2017 to 2020
$1.9M
NEI NIH HHS R01 EY002593NIA NIH HHS P01 AG051459NIDA NIH HHS R01 DA023999NIDA NIH HHS R37 DA023999NIDDK NIH HHS R01 DK111178
6 · The paper itself

Abstract

objectivesPhytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB

methodsWe applied immunohistochemical labeling of CB

resultsUsing three-dimensional reconstruction from serial sections we demonstrated numerous discontinuous segments of anti-CB

conclusionsOur immunohistochemical and ultrastructural study demonstrates the morphological substrate for cannabinoid-conducted feeding behavior via retrograde dis-inhibition of hunger-promoting AgRP/NPY neurons.

Indexed as

Agouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusAxonsMiceMice, Inbred C57BLNeuropeptide YReceptor, Cannabinoid, CB1Agouti-Related ProteinNeuropeptide YReceptor, Cannabinoid, CB13D reconstructionAgouti-related proteinArcuate nucleusElectron microscopyHypothalamusNeuropeptide Y

Identifiers

PMID28377876
PMCPMC5369208
OpenAlexW2580355139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.