ArticleMolecular metabolism2017
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for
Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
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- A Sex-Specific Minimal CpG-Based Model for Biological Aging UsingInternational journal of molecular sciences · 2025Article
- Revisited guidelines for metabolic tolerance tests in mice.Lab animal · 2025Review
- A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice.iScience · 2024Article
- Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic β cells.JCI insight · 2024Article
- An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition.Diabetes · 2022Article
- Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion.Diabetes · 2022Article
- Regenerating islet-derived protein 3α: A promising therapy for diabetes. Preliminary data in rodents and in humans.Heliyon · 2022Article
- Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation.Diabetes · 2022Article
- Article
- Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging.Signal transduction and targeted therapy · 2022Article
- Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding.BMC genomics · 2022Article
- Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.Diabetologia · 2021Article
- Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population.Nutrients · 2020Article
- Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development.Journal of personalized medicine · 2020Article
- Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice.Molecular nutrition & food research · 2020Article
- Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding.Molecular metabolism · 2020Article
- The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.Biomolecules · 2020Article
- Maternal dietary resistant starch does not improve piglet's gut and liver metabolism when challenged with a high fat diet.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
31 authors at 9 institutions in 5 countries.
Funding
Abstract
objectiveIn type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell dysfunction by analyzing multiple mouse strains in parallel under metabolic stress.
methodsMale mice from six commonly used non-diabetic mouse strains were fed a high fat or regular chow diet for three months. Pancreatic islets were extracted and phenotypic measurements were recorded at 2 days, 10 days, 30 days, and 90 days to assess diabetes progression. RNA-Seq was performed on islet tissue at each time-point and integrated with the phenotypic data in a network-based analysis.
resultsA module of co-expressed genes was selected for further investigation as it showed the strongest correlation to insulin secretion and oral glucose tolerance phenotypes. One of the predicted network hub genes was
conclusionOur results suggest a role for
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.