ArticleAnnals of medicine and surgery (2012)2017
An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy.
Article in Annals of medicine and surgery (2012), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Predictors of Gallstones in Patients With Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD).Cureus · 2025Article
- Gallstones increase the risk of nonalcoholic fatty liver: A case-control study.Health science reports · 2024Article
- Review
- Association between metabolically healthy overweight/obesity and gallstones in Chinese adults.Nutrition & metabolism · 2023Article
- Clinico-epidemiology and aetiopathogenesis of gallstone disease in the South Asian region: a scoping review protocol.BMJ open · 2022Article
- Physical activity can reduce the prevalence of gallstone disease among males: An observational study.Medicine · 2020Observational
- Association Between Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome with Gallstone Disease, South Iran: A Population-Based Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Strong association between metabolically-abnormal obesity and gallstone disease in adults under 50 years.BMC gastroenterology · 2019Article
- Article
- Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population.Medicine · 2017Article
- Incidence of nonalcoholic fatty liver disease in patients undergoing laparoscopic cholecystectomy.Journal of family medicine and primary careArticle
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveRecognition of Non alcoholic fatty liver disease (NAFLD) and metabolic syndrome in patients with gallstones undergoing laparoscopic or open cholecystectomy, along with it we will also study the life style of patients with gall stones.
backgroundPatients with gallstones have associated NAFLD, with concurrent metabolic syndrome and these ailments share similar factors for example obesity, hypertriglyceridemia and diabetes mellitus. Factors like body mass index, gender, raised lipid levels, use of contraceptives and alcohol and having diabetes, physical inactiveness, multiparous women, water with excessive iron content, metabolic syndrome, and NAFLD are accountable factors for gallstones formation. METHODOLOGY: This was a case series done at Surgical Unit 1 of Civil Hospital Karachi. Selective samples of 88 patients were included. Duration was 3 months. We included both sexes with ultrasound proof of gall stone irrespective of cholecystitis. Excluded patients with history of seropositive viral hepatitis, autoimmune and wilson's disease. As these conditions can act as a confounder to our variables.
resultsNafld was present in 62.5%(n = 55) while 28.4% (n = 25) had metabolic syndrome. 26.94% had BMI less than 18, 32.12 had BMI between 18 and 25 and majority had BMI greater than 25 i.e in 40.93%. Of all 46.6% had a family history of cholelithiasis. Gallstone patients with NAFLD reported about their first degree relative being suffering from cholelithiasis at a significant p-value of 0.034 while this was not significant in cases of metabolic syndrome and the p -value was 0.190.
conclusionWe found association of metabolic syndrome with gallstones and NAFLD. Non alcoholic fatty liver was highly prevalent in our study subjects. Huge percentage of first degree relatives of gall stone patients had gallstones and this relation was more pronounced patients who had associated NAFLD.
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