Evidence map›Paper›PMID 28377769›Full record

ArticleFrontiers in immunology2017

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice.

Zi-Wei Ye, Shuofeng Yuan, Kwok-Man Poon, Lei Wen, Dong Yang, Zehua Sun, Cun Li, Meng Hu, Huiping Shuai, Jie Zhou and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

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  8. Antiviral Approaches against Influenza Virus.Clinical microbiology reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Zi-Wei YeDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Shuofeng YuanDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Kwok-Man PoonDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Lei WenDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Dong YangDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Zehua SunDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Cun LiDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Meng HuDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Huiping ShuaiDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Jie ZhouDepartment of Microbiology, The University of Hong Kong, Hong Kong; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong.
Mei-Yun ZhangDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Bo-Jian ZhengDepartment of Microbiology, The University of Hong Kong , Hong Kong.
Hin ChuDepartment of Microbiology, The University of Hong Kong, Hong Kong; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong.
Kwok-Yung YuenDepartment of Microbiology, The University of Hong Kong, Hong Kong; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong.
University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engaging the antibody-dependent cell-mediated cytotoxicity (ADCC) for killing of virus-infected cells and secretion of antiviral cytokines and chemokines was incorporated as one of the important features in the design of universal influenza vaccines. However, investigation of the ADCC epitopes on the highly immunogenic influenza hemagglutinin (HA) head region has been rarely reported. In this study, we determined the ADCC and antiviral activities of two putative ADCC epitopes, designated E1 and E2, on the HA head of a pandemic H1N1 influenza virus

Indexed as

antibody-dependent cell-mediated cytotoxicityH1N1 influenza virushemagglutininlung damagemice

Identifiers

PMID28377769
PMCPMC5359280
OpenAlexW2598904974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.