Evidence map›Paper›PMID 28377768›Full record

ReviewFrontiers in immunology2017

Role of Natural Killer Cells in HIV-Associated Malignancies.

Fabio E Leal, Thomas A Premeaux, Mohamed Abdel-Mohsen, Lishomwa C Ndhlovu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Fabio E LealPrograma de Oncovirologia, Instituto Nacional de Cancer , Rio de Janeiro , Brazil.
Thomas A PremeauxDepartment of Tropical Medicine, Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii , Honolulu, HI , USA.
Mohamed Abdel-MohsenBlood Systems Research Institute, San Francisco, CA, USA; University of California, San Francisco, CA, USA.
Lishomwa C NdhlovuDepartment of Tropical Medicine, Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii , Honolulu, HI , USA.
University of Hawaiʻi at Mānoa · USBlood Systems Research Institute · USInstituto Nacional do Câncer · BR

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
Role of Host Glycosylation in the Galectin-9-Mediated Reversal of HIV LatencyR21AI129636 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2017 to 2018
$496k
Reversal of Adaptive Immune Dysfunction in Shock and Kill HIV Cure StrategiesR21AI122393 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI NDHLOVU, LISHOMWA C · 2016 to 2017
$471k
NIAID NIH HHS R21 AI122393NIAID NIH HHS R21 AI129636NIGMS NIH HHS P20 GM103466
6 · The paper itself

Abstract

Now in its fourth decade, the burden of HIV disease still persists, despite significant milestone achievements in HIV prevention, diagnosis, treatment, care, and support. Even with long-term use of currently available antiretroviral therapies (ARTs), eradication of HIV remains elusive and now poses a unique set of challenges for the HIV-infected individual. The occurrence of HIV-associated non-AIDS-related comorbidities outside the scope of AIDS-defining illnesses, in particular non-AIDS-defining cancers, is much greater than the age-matched uninfected population. The underlying mechanism is now recognized in part to be related to the immune dysregulated and inflammatory status characteristic of HIV infection that persists despite ART. Natural killer (NK) cells are multifunctional effector immune cells that play a critical role in shaping the innate immune responses to viral infections and cancer. NK cells can modulate the adaptive immune response

Indexed as

ADCCantiretroviral therapycancereradication and controlHIVlymphomanatural killer cells

Identifiers

PMID28377768
PMCPMC5359293
OpenAlexW2598252943

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.