ArticleFrontiers in behavioral neuroscience2017
Lesions of the Orbitofrontal but Not Medial Prefrontal Cortex Affect Cognitive Judgment Bias in Rats.
Article in Frontiers in behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Article
- Trait sensitivity to positive feedback is a predisposing factor for several aspects of compulsive alcohol drinking in male rats: behavioural, physiological, and molecular correlates.Psychopharmacology · 2024Article
- Application of Cognitive Bias Testing in Neuropsychiatric Disorders: A Mini-Review Based on Animal Studies.Frontiers in behavioral neuroscience · 2022Review
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Authors and funding
2 authors.
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Abstract
Neuroimaging studies in humans have recently shown that the prefrontal cortex (PFC) and orbitofrontal cortex (OFC) mediate bias in the judgment of forthcoming events. In the present study, we sought to determine whether cognitive judgment bias (CJB) is also dependent on these prefrontal regions in non-human animals. For this, we trained a cohort of rats in the ambiguous-cue interpretation (ACI) paradigm, subjected them to excitotoxic lesions in the medial PFC (mPFC) and OFC, and tested the effects of neuronal loss within these regions on CJB. Comparison of the lesions' behavioral effects in the ACI paradigm revealed that neuronal loss within the OFC but not within the mPFC influences the interpretation of ambiguous cues by animals. Our findings demonstrate the specific involvement of the OFC in CJB in rats.
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