ArticleFrontiers in systems neuroscience2017
Breaking the Excitation-Inhibition Balance Makes the Cortical Network's Space-Time Dynamics Distinguish Simple Visual Scenes.
Article in Frontiers in systems neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- How far neuroscience is from understanding brains.Frontiers in systems neuroscience · 2023Article
- Local networks from different parts of the human cerebral cortex generate and share the same population dynamic.Cerebral cortex communications · 2022Article
- Morphine Differentially Alters the Synaptic and Intrinsic Properties of D1R- and D2R-Expressing Medium Spiny Neurons in the Nucleus Accumbens.Frontiers in synaptic neuroscience · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Brain dynamics are often taken to be temporal dynamics of spiking and membrane potentials in a balanced network. Almost all evidence for a balanced network comes from recordings of cell bodies of few single neurons, neglecting more than 99% of the cortical network. We examined the space-time dynamics of excitation and inhibition simultaneously in dendrites and axons over four visual areas of ferrets exposed to visual scenes with stationary and moving objects. The visual stimuli broke the tight balance between excitation and inhibition such that the network exhibited longer episodes of net excitation subsequently balanced by net inhibition, in contrast to a balanced network. Locally in all four areas the amount of net inhibition matched the amount of net excitation with a delay of 125 ms. The space-time dynamics of excitation-inhibition evolved to reduce the complexity of neuron interactions over the whole network to a flow on a low-(3)-dimensional manifold within 80 ms. In contrast to the pure temporal dynamics, the low dimensional flow evolved to distinguish the simple visual scenes.
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