ArticleFrontiers in neuroanatomy2017
Computational Model of Recurrent Subthalamo-Pallidal Circuit for Generation of Parkinsonian Oscillations.
Article in Frontiers in neuroanatomy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- Computational model for control of hand movement in Parkinson's disease using deep brain stimulation.Experimental brain research · 2025Article
- Unraveling the Complexity of Parkinson's Disease: Insights into Pathogenesis and Precision Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Multiple time delay induced Hopf bifurcation of a cortex - basal ganglia model for Parkinson's Disease.Cognitive neurodynamics · 2024Article
- Computational study of associations between the synaptic conductance of STN and GPe and the development of Parkinson's disease.Cognitive neurodynamics · 2024Article
- Synaptic Changes in Pallidostriatal Circuits Observed in the Parkinsonian Model Triggers Abnormal Beta Synchrony with Accurate Spatio-temporal Properties across the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dynamics of parkinsonian oscillations mediated by transmission delays in a mean-field model of the basal ganglia.Frontiers in cellular neuroscience · 2024Article
- Identifying good practices for detecting inter-regional linear functional connectivity from EEG.NeuroImage · 2023Article
- The network configuration in Parkinsonian state compensates network activity change caused by loss of dopamine.Physiological reports · 2023Article
- Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop.Scientific reports · 2022Article
- The theoretical mechanism of Parkinson's oscillation frequency bands: a computational model study.Cognitive neurodynamics · 2021Article
- A biologically constrained spiking neural network model of the primate basal ganglia with overlapping pathways exhibits action selection.The European journal of neuroscience · 2021Article
- Interaction of Indirect and Hyperdirect Pathways on Synchrony and Tremor-Related Oscillation in the Basal Ganglia.Neural plasticity · 2021Article
- Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.The Journal of physiology · 2020Article
- Self-Tuning Deep Brain Stimulation Controller for Suppression of Beta Oscillations: Analytical Derivation and Numerical Validation.Frontiers in neuroscience · 2020Article
- Multistable properties of human subthalamic nucleus neurons in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- The beta oscillation conditions in a simplified basal ganglia network.Cognitive neurodynamics · 2019Article
- A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity.Frontiers in neural circuits · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease is a movement disorder caused by dopamine depletion in the basal ganglia. Abnormally synchronized neuronal oscillations between 8 and 15 Hz in the basal ganglia are implicated in motor symptoms of Parkinson's disease. However, how these abnormal oscillations are generated and maintained in the dopamine-depleted state is unknown. Based on neural recordings in a primate model of Parkinson's disease and other experimental and computational evidence, we hypothesized that the recurrent circuit between the subthalamic nucleus (STN) and the external segment of the globus pallidus (GPe) generates and maintains parkinsonian oscillations, and that the cortical excitatory input to the STN amplifies them. To investigate this hypothesis through computer simulations, we developed a spiking neuron model of the STN-GPe circuit by incorporating electrophysiological properties of neurons and synapses. A systematic parameter search by computer simulation identified regions in the space of the intrinsic excitability of GPe neurons and synaptic strength from the GPe to the STN that reproduce normal and parkinsonian states. In the parkinsonian state, reduced firing of GPe neurons and increased GPe-STN inhibition trigger burst activities of STN neurons with strong post-inhibitory rebound excitation, which is usually subject to short-term depression. STN neuronal bursts are shaped into the 8-15 Hz, synchronous oscillations via recurrent interactions of STN and GPe neurons. Furthermore, we show that cortical excitatory input to the STN can amplify or suppress pathological STN oscillations depending on their phase and strength, predicting conditions of cortical inputs to the STN for suppressing oscillations.
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