ArticleScientific reports2017
Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 91 citations in OpenAlex.
- Amplified Light Absorption with Nanomaterials for Enhanced Photoacoustic Imaging in Biomedical Research: A Review.Bioengineering (Basel, Switzerland) · 2026Review
- Enhanced Dye-Sensitized Mechanosensation Utilizing Pulsed and Digitally Modulated Light.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multi-Scale Volumetric Dynamic Optoacoustic and Laser Ultrasound (OPLUS) Imaging Enabled by Semi-Transparent Optical Guidance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review.Journal of biomedical optics · 2024Review
- Review of imaging test phantoms.Journal of biomedical optics · 2023Review
- Article
- Low-Cost Laser-Acoustic PVC Identification System Based on a Simple Neural Network.Sensors (Basel, Switzerland) · 2022Article
- Morphology-dependent resonance enhanced nonlinear photoacoustic effect in nanoparticle suspension: a temporal-spatial model.Biomedical optics express · 2021Article
- Deep learning enabled real-time photoacoustic tomography system via single data acquisition channel.Photoacoustics · 2021Article
- Nonlinear mechanisms in photoacoustics-Powerful tools in photoacoustic imaging.Photoacoustics · 2021Review
- Internal-Illumination Photoacoustic Tomography Enhanced by a Graded-Scattering Fiber Diffuser.IEEE transactions on medical imaging · 2021Article
- Y-Net: Hybrid deep learning image reconstruction for photoacoustic tomography in vivo.Photoacoustics · 2020Article
- Optical and Thermal Properties of Laser-Ablated Platinum Nanoparticles Graphene Oxide Composite.International journal of molecular sciences · 2019Article
- Listening to tissues with new light: recent technological advances in photoacoustic imaging.Journal of optics (2010) · 2019Article
- Review of cost reduction methods in photoacoustic computed tomography.Photoacoustics · 2019Review
- Transducer-matched multipulse excitation for signal-to-noise ratio improvement in diode laser-based photoacoustic systems.Journal of biomedical optics · 2019Article
- Article
- Molecular Photoacoustic Contrast Agents: Design Principles & Applications.Photochemistry and photobiology · 2018Review
- Optoacoustic signal excitation with a tone-burst of short pulses.Photoacoustics · 2018Article
- Review of Low-Cost Photoacoustic Sensing and Imaging Based on Laser Diode and Light-Emitting Diode.Sensors (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoacoustic sensing and imaging techniques have been studied widely to explore optical absorption contrast based on nanosecond laser illumination. In this paper, we report a long laser pulse induced dual photoacoustic (LDPA) nonlinear effect, which originates from unsatisfied stress and thermal confinements. Being different from conventional short laser pulse illumination, the proposed method utilizes a long square-profile laser pulse to induce dual photoacoustic signals. Without satisfying the stress confinement, the dual photoacoustic signals are generated following the positive and negative edges of the long laser pulse. More interestingly, the first expansion-induced photoacoustic signal exhibits positive waveform due to the initial sharp rising of temperature. On the contrary, the second contraction-induced photoacoustic signal exhibits exactly negative waveform due to the falling of temperature, as well as pulse-width-dependent signal amplitude. An analytical model is derived to describe the generation of the dual photoacoustic pulses, incorporating Gruneisen saturation and thermal diffusion effect, which is experimentally proved. Lastly, an alternate of LDPA technique using quasi-CW laser excitation is also introduced and demonstrated for both super-contrast in vitro and in vivo imaging. Compared with existing nonlinear PA techniques, the proposed LDPA nonlinear effect could enable a much broader range of potential applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.