Evidence map›Paper›PMID 28377600›Full record

ArticleScientific reports2017

Low-level laser facilitates alternatively activated macrophage/microglia polarization and promotes functional recovery after crush spinal cord injury in rats.

Ji Wei Song, Kun Li, Zhuo Wen Liang, Chen Dai, Xue Feng Shen, Yu Ze Gong, Shuang Wang, Xue Yu Hu, Zhe Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  13. Photobiomodulation therapy.JADA foundational science · 2025
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  18. The Effect of Photobiomodulation andJournal of lasers in medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ji Wei SongDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Kun LiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhuo Wen LiangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Chen DaiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Xue Feng ShenDepartment of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Fourth Military Medical University, Xi'an, Shaanxi, China.
Yu Ze GongDepartment of Physics, Institute of Photonics and Photon-Technology, Northwest University, Xi'an, Shaanxi, China.
Shuang WangDepartment of Physics, Institute of Photonics and Photon-Technology, Northwest University, Xi'an, Shaanxi, China.
Xue Yu HuDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. huxueyu@fmmu.edu.cn.
Zhe WangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. wangzhe@fmmu.edu.cn.
Air Force Medical University · CNNorthwest University · CNXijing Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely used in neurotrauma and neurodegenerative diseases. However, the influence of low-level laser on polarization of macrophage/microglia following spinal cord injury remains unknown. The present study applied low-level laser therapy on a crush spinal cord injury rat model. Using immunofluorescence, flow cytometry, RT-qPCR, and western blot assays, we found that low-level laser therapy altered the polarization state to a M2 tendency. A greater number of neurons survived in the pare injury site, which was accompanied by higher BBB scores in the LLLT group. Furthermore, low-level laser therapy elevated expression of interleukin 4 (IL-4) and interleukin 13 (IL-13). Results from this study show that low-level laser therapy has the potential for reducing inflammation, regulating macrophage/microglia polarization, and promoting neuronal survival. These beneficial effects demonstrate that low-level laser therapy may be an effective candidate for clinical treatment of spinal cord injury.

Indexed as

Laser TherapyAnimalsAstrocytesBehavior, AnimalBiomarkersCytokinesDisease Models, AnimalInflammation MediatorsMacrophage ActivationMacrophagesMicrogliaNeuronsNeuroprotectionPhenotypeRatsRecovery of FunctionBiomarkersCytokinesInflammation Mediators

Identifiers

PMID28377600
PMCPMC5428709
OpenAlexW2597913683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.