ArticleAnnals of Saudi medicine
Myelopathy associated with age-related cervical disc herniation: a retrospective review of magnetic resonance images.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Early Diagnosis of Degenerative Cervical Myelopathy: A Systematic Review of Current Evidence.Global spine journal · 2026Review
- Pain catastrophizing and postoperative satisfaction in cervical disc herniation: a 6-month prospective cohort study.BMC musculoskeletal disorders · 2026Article
- A Review of Pathophysiology, Molecular Mechanisms, and Omics Approaches of Spinal Cord Injury.International journal of molecular sciences · 2025Review
- Article
- Atraumatic Cervical Disc Herniation With Rapidly Progressive Myelopathy in a 47-Year-Old Male: A Case Report.Cureus · 2024Article
- Feasibility of postoperative diffusion-weighted imaging to assess representations of spinal cord microstructure in cervical spondylotic myelopathy.Neurosurgical focus · 2023Article
- Differences in the Incidence of Symptomatic Cervical and Lumbar Disc Herniation According to Age, Sex and National Health Insurance Eligibility: A Pilot Study on the Disease's Association with Work.International journal of environmental research and public health · 2018Article
- Expression of miR-625 and Fas in cervical vertebral cartilage endplate.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCervical intervertebral disc herniation can lead to myelopathy. Aging is an established variable related to spondylotic myelopathy. Studying this association will help in controlling the increase in spondylotic myelopathy with age.
objectivesTo study the association between cervical disc level, its direction, and the frequency of my-elopathy with age, and to assess the epidemiology of age-related cervical disc herniation and myelopathy.
designRetrospective review of magnetic resonance (MR) images.
settingTertiary referral hospital. PATIENTS AND
methodsWe studied the MR images of adults patients ( > 18 years of age) referred to our department between 2001 and 2012 for suspected cervical spondylopathy. The direction and severity of herniation and the presence of myelopathy was determined for spinal levels C2 to C7. MAIN OUTCOME MEASURE(S): Relationship between age-related cervical disc herniation and myelopathy.
resultsWe studied 6584 patient MR images, which included 2402 males (39.1%) and 3737 females (60.9%). The frequency of myelopathy increased with age from 0.6% in patients < 20 years of age, reaching 9.1% in patients > 70 years of age. The most common level affected by myelopathy was C5-C6. In elderly patients ( > 60 years), the C3-C4 level became the predominant level affected by myelopathy. Likewise, the frequency of central disc herniation increased significantly (P < .001) with age at all cervical levels. Furthermore, upper cervical levels showed a higher frequency of central disc herniation than lower cervical levels in the elderly.
conclusionThe increased frequency of central disc herniation with age suggest an important, and probably a cause-effect relationship, between herniation and myelopathy. LIMITATIONS: We were unable to access clinical data or electrophysiological studies to correlate with MR image findings.
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