ArticleThorax2018
One evidence base; three stories: do opioids relieve chronic breathlessness?
Article in Thorax, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Palliative drug treatments for breathlessness in cystic fibrosis.The Cochrane database of systematic reviews · 2020Pooled it
- Holistic services for people with advanced disease and chronic breathlessness: a systematic review and meta-analysis.Thorax · 2019Pooled it
- Palliative drug treatments for breathlessness in cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Comparing the effectiveness, cost-effectiveness and implementation of low-dose oral modified release morphine in people with chronic breathlessness: a synopsis of a RCT and process evaluation.Health technology assessment (Winchester, England) · 2026Trial
- Trial
- Oral morphine drops for prompt relief of breathlessness in patients with advanced cancer-a randomized, double blinded, crossover trial of morphine sulfate oral drops vs. morphine hydrochloride drops with ethanol (red morphine drops).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- Trial
- Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo-controlled trial.ESC heart failure · 2019Trial
- Trial
- A Systematic Review and Meta-Analysis on Opioid Management of Dyspnea in Cancer Patients.Cancers · 2025Review
- Opioids in Treatment of Refractory Dyspnea in Chronic Obstructive Pulmonary Disease: Yes, No or Maybe.Journal of personalized medicine · 2024Review
- Opioid prescribing patterns among medical practitioners in New South Wales, Australia.Drug and alcohol review · 2023Article
- Modified-release morphine or placebo for chronic breathlessness: the MABEL trial protocol.ERJ open research · 2023Article
- Dyspnea in Oncological Patients: a Brain Teaser.European cardiology · 2023Review
- Off-label use in adult palliative care - more common than expected. A retrospective chart review.European journal of hospital pharmacy : science and practice · 2022Article
- Chronic Obstructive Pulmonary Disease Combined with Interstitial Lung Disease.Tuberculosis and respiratory diseases · 2022Review
- Do guidelines influence breathlessness management in advanced lung diseases? A multinational survey of respiratory medicine and palliative care physicians.BMC pulmonary medicine · 2022Article
- Review
- Care for Older People with Dementia During COVID-19 Pandemic.SN comprehensive clinical medicine · 2021Review
- Use of short-acting opioids in the management of breathlessness: an evidence-based review.Current opinion in supportive and palliative care · 2020Review
Corrections and comments
- Comment on
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.