Evidence map›Paper›PMID 28377464›Full record

ArticleThe EMBO journal2017

STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.

Léa P Wilhelm, Corinne Wendling, Benoît Védie, Toshihide Kobayashi, Marie-Pierre Chenard, Catherine Tomasetto, Guillaume Drin, Fabien Alpy

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 3 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 3 syntheses or guidelines pooled it, 256 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
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  18. Organelle contact sites in cancer cells.Cell death & disease · 2026
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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Léa P WilhelmFunctional Genomics and Cancer Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Corinne WendlingFunctional Genomics and Cancer Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Benoît VédieAP-HP (Assistance Publique - Hôpitaux de Paris), Hôpital Européen Georges Pompidou, Service de Biochimie, Paris, France.
Toshihide KobayashiUniversité de Strasbourg, Illkirch, France.
Marie-Pierre ChenardFunctional Genomics and Cancer Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Catherine TomasettoFunctional Genomics and Cancer Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France catherine-laure.tomasetto@igbmc.fr fabien.alpy@igbmc.fr.ORCID 0000-0002-1811-5848
Guillaume DrinUniversité Côte d'Azur, CNRS Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
Fabien AlpyFunctional Genomics and Cancer Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France catherine-laure.tomasetto@igbmc.fr fabien.alpy@igbmc.fr.ORCID 0000-0002-0526-0720
Centre National de la Recherche Scientifique · FRAssistance Publique – Hôpitaux de Paris · FRInstitut de génétique et de biologie moléculaire et cellulaire · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

StAR-related lipid transfer domain-3 (STARD3) is a sterol-binding protein that creates endoplasmic reticulum (ER)-endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts the intracellular distribution of this lipid was ill-defined. Here, by using

Indexed as

Biological TransportCarrier ProteinsCell MembraneCholesterolEndoplasmic ReticulumEndosomesHeLa CellsHumansMembrane ProteinsProtein BindingVesicular Transport ProteinsCarrier ProteinsCholesterolMembrane ProteinsSTARD3 protein, humanVAPA protein, humanVesicular Transport Proteinscholesterolendoplasmic reticulumendosomelipid transfer proteinmembrane contact site

Identifiers

PMID28377464
PMCPMC5430228
OpenAlexW2604801873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.