Evidence map›Paper›PMID 28377429›Full record

ArticleJournal of the American Heart Association2017

Circulating microRNAs: Potential Markers of Cardiotoxicity in Children and Young Adults Treated With Anthracycline Chemotherapy.

Kasey J Leger, David Leonard, Danelle Nielson, James A de Lemos, Pradeep P A Mammen, Naomi J Winick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

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  10. Revolutionising Cardio-Oncology Care with Precision Genomics.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kasey J LegerDepartment of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA kasey.leger@seattlechildrens.org.
David LeonardDepartment of Clinical Research, Children's Medical Center, Dallas, TX.
Danelle NielsonDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
James A de LemosDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Pradeep P A MammenDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Naomi J WinickDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
The University of Texas Southwestern Medical Center · USChildren's Medical Center · USSeattle Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiomarkers for early detection of anthracycline (AC)-induced cardiotoxicity may allow cardioprotective intervention before irreversible damage. Circulating microRNAs (miRNAs) are promising biomarkers of cardiovascular disease, however, have not been studied in the setting of AC-induced cardiotoxicity. This study aimed to identify AC-induced alterations in plasma miRNA expression in children and correlate expression with markers of cardiac injury. METHODS AND

resultsCandidate plasma profiling of 24 miRNAs was performed in 33 children before and after a cycle of AC (n=24) or noncardiotoxic chemotherapy (n=9). Relative miRNA changes between the pre- and postcycle time points (6, 12, and 24 hours) were determined within each treatment group and compared across groups. Plasma miRNA expression patterns were further explored with respect to AC dose and high-sensitivity troponin T. Greater chemotherapy-induced dysregulation was observed in this panel of candidate, cardiac-related plasma miRNAs in patients receiving anthracyclines compared with those receiving noncardiotoxic chemotherapy (24-hour MANOVA;

conclusionsIn this pilot study, cardiac-related plasma miRNAs are dysregulated following ACs. Plasma miR-29b and -499 are acutely elevated post-AC, with dose response relationships observed with anthracycline dose and markers of cardiac injury. Further evaluation of miRNAs may provide mechanistic insight into AC-induced cardiotoxicity and yield biomarkers to facilitate earlier intervention to mitigate cardiotoxicity.

Indexed as

AdolescentAge FactorsAnthracyclinesAntibiotics, AntineoplasticCardiotoxicityCase-Control StudiesChildChild, PreschoolDose-Response Relationship, DrugEarly DiagnosisFemaleGenetic MarkersHeart DiseasesHumansInfantMaleAnthracyclinesAntibiotics, AntineoplasticGenetic MarkersMicroRNAsMIRN29a microRNA, humanMIRN499 microRNA, humanTroponin TanthracyclinecancercardiotoxicitymicroRNApediatric

Identifiers

PMID28377429
PMCPMC5532993
OpenAlexW2604367546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.