Evidence map›Paper›PMID 28377401›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2017

Enrico Bertaggia, Kristian K Jensen, Jose Castro-Perez, Yimeng Xu, Gilbert Di Paolo, Robin B Chan, Liangsu Wang, Rebecca A Haeusler

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 116 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Bile acid signaling, metabolism, and aging.Liver research (Beijing, China) · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Bile acid metabolism in type 2 diabetes mellitus.Nature reviews. Endocrinology · 2025
    Review
  18. Article
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Enrico BertaggiaDepartment of Pathology and Cell Biology, Columbia University, New York, New York.
Kristian K JensenDiabetes Department, Merck Research Laboratories, Kenilworth, New Jersey; and.
Jose Castro-PerezDiabetes Department, Merck Research Laboratories, Kenilworth, New Jersey; and.
Yimeng XuDepartment of Pathology and Cell Biology, Columbia University, New York, New York.
Gilbert Di PaoloDepartment of Pathology and Cell Biology, Columbia University, New York, New York.
Robin B ChanDepartment of Pathology and Cell Biology, Columbia University, New York, New York.
Liangsu WangDiabetes Department, Merck Research Laboratories, Kenilworth, New Jersey; and.
Rebecca A HaeuslerDepartment of Pathology and Cell Biology, Columbia University, New York, New York; rah2130@cumc.columbia.edu.
Columbia University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USDenali Therapeutics (United States) · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DOMENICO ACCILI · 2003 to 2026
$36.7M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KOUSTENI, STAVROULA · 1986 to 2025
$7.8M
Mechanisms linking insulin action with lipoprotein metabolismR01HL125649 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAEUSLER, REBECCA ANNE · 2015 to 2023
$4.2M
Role of FoxO1 in Lipid MetabolismR00HL111206 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAEUSLER, REBECCA ANNE · 2014 to 2016
$747k
NCATS NIH HHS UL1 TR001873NHLBI NIH HHS R00 HL111206NHLBI NIH HHS R01 HL125649NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK063608NIDDK NIH HHS T32 DK007328
6 · The paper itself

Abstract

Bile acids (BAs) are cholesterol derivatives that regulate lipid metabolism, through their dual abilities to promote lipid absorption and activate BA receptors. However, different BA species have varying abilities to perform these functions. Eliminating 12α-hydroxy BAs in mice via

Indexed as

AnimalsBile Acids and SaltsDietary FatsDiet, High-FatDiet, WesternFatty LiverIntestinal AbsorptionLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutSteroid 12-alpha-HydroxylaseWeight GainBile Acids and SaltsDietary FatsSteroid 12-alpha-Hydroxylasebile acidsdiabeteslipid absorptionobesitytriglyceride

Identifiers

PMID28377401
PMCPMC5582885
OpenAlexW2604117018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.