ArticleBehavioural brain research2017
Effects of social deprivation on social and depressive-like behaviors and the numbers of oxytocin expressing neurons in rats.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Early life adversity disrupts adult social reward motivation.bioRxiv : the preprint server for biology · 2026Article
- Neural signaling mechanisms in depression: bridging classical monoamine hypotheses, animal models, and emerging antidepressant strategies.Frontiers in cell and developmental biology · 2026Review
- Early maternal separation potentiates the impact of later social isolation in inducing depressive-like behavior via oxidative stress in adult rats.Psychopharmacology · 2025Article
- Cerebrolysin Induces Dendritic Tree Plastic Changes and BDNF Increase in the Amygdala of Male Rats with Maternal Deprivation.Neurochemical research · 2025Article
- Differential Roles of Oxytocin Receptors in the Prefrontal Cortex and Nucleus Accumbens on Cocaine Self-Administration and Reinstatement of Cued Cocaine Seeking in Male Rats.The international journal of neuropsychopharmacology · 2023Article
- Here I am, why don't you answer me? Sensitivity to social responsiveness in domestic chicks.iScience · 2023Article
- Comparison of the effect of postweaning social isolation, enriched environment, and exercise training on learning and memory functions in rats.Turkish journal of medical sciences · 2023Article
- Caring animals and the ways we wrong them.Biology & philosophy · 2023Article
- Impact of prolonged chronic social isolation stress on behavior and multifractal complexity of metabolic rate inFrontiers in behavioral neuroscience · 2023Article
- Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders.International immunopharmacology · 2022Article
- Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio).Scientific reports · 2022Article
- Integrative Model of Human-Animal Interactions: A One Health-One Welfare Systemic Approach to Studying HAI.Frontiers in veterinary science · 2022Article
- Interdisciplinary approach of Yalom's group therapy factors: A theoretical model for including animal presence in social work education and practice.Frontiers in veterinary science · 2022Article
- Paradoxical changes in mood-related behaviors on continuous social isolation after weaning.Experimental brain research · 2021Article
- Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin.Neuropharmacology · 2021Review
- "Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress.Neurobiology of stress · 2021Article
- Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus.Scientific reports · 2020Article
- The Impact of Early Postnatal and Juvenile Social Environments on the Effects of Chronic Intranasal Oxytocin in the Prairie Vole.Frontiers in behavioral neuroscience · 2019Article
- Rapid nonapeptide synthesis during a critical period of development in the prairie vole: plasticity of the paraventricular nucleus of the hypothalamus.Brain structure & function · 2018Article
- Anhedonic behavior and γ-amino butyric acid during a sensitive period in female rats exposed to early adversity.Journal of psychiatric research · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Social isolation is a known stressor that negatively impacts the well-being of social species. In rodents, social deprivation experienced either before or after weaning profoundly impacts adult behavioral and neuroendocrine profiles. This study compared the effects of post-natal and post-weaning social deprivation on behavioral profiles and hypothalamic oxytocin (OT) neurons. Male and female Sprague-Dawley rats were assigned to two post-natal groups, maternally separated (MS) or non-MS. MS pups were separated from their mothers for 4h daily during post-natal days 2-21 while non-MS litters remained undisturbed. Animals were then weaned and assigned to single or group housing conditions (SH/GH). Social behaviors were evaluated two weeks later and at 2-3 months of age, depressive-like behavioral profiles were assessed using the forced swim and sucrose preference tests. Animals were euthanized, and hypothalamic OT neurons were quantified. Post-weaning isolation significantly impacted behavioral profiles, with SH animals displaying more social behaviors than GH animals. SH animals also exhibited more immobility behavior in the forced swim test and a decreased sucrose preference. Effects of sex and MS were relatively limited. Correlation analyses revealed an inverse relationship between the display of antagonistic social behaviors and the numbers of OT cells in the anterior parvicellular division of the paraventricular nucleus (PVNap). There were no correlations between numbers of OT neurons and prosocial or depressive-like behaviors. Our results demonstrate a rapid and persistent disruption of behaviors in SH animals and suggest that some of these effects may be associated with numbers of OT neurons in the PVNap.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.