Evidence map›Paper›PMID 28377170›Full record

ArticleBioorganic & medicinal chemistry2017

Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes.

Douglas R Rice, María de Lourdes Betancourt Mendiola, Claribel Murillo-Solano, Lisa A Checkley, Michael T Ferdig, Juan C Pizarro, Bradley D Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Douglas R RiceDepartment of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
María de Lourdes Betancourt MendiolaDepartment of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
Claribel Murillo-SolanoDepartment of Tropical Medicine, J Bennett Johnston Building, 1430 Tulane Avenue, Tulane University, New Orleans, LA 70112, USA.
Lisa A CheckleyDepartment of Biological Science, Galvin Life Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Michael T FerdigDepartment of Biological Science, Galvin Life Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Juan C PizarroDepartment of Tropical Medicine, J Bennett Johnston Building, 1430 Tulane Avenue, Tulane University, New Orleans, LA 70112, USA.
Bradley D SmithDepartment of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA. Electronic address: smith.115@nd.edu.
University of Notre Dame · USTulane University · US

Funding

PROMOTERS AND INHIBITORS OF MEMBRANE FUSIONR01GM059078 · NIGMS · UNIVERSITY OF NOTRE DAME · PI SMITH, BRADLEY D · 1999 to 2019
$5.8M
Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
NIGMS NIH HHS R01 GM059078NIGMS NIH HHS T32 GM075762
6 · The paper itself

Abstract

This study measured the antiplasmodial activity of nine zinc-dipicolylamine (ZnDPA) complexes against three strains of Plasmodium falciparum, the causative parasite of malaria. Growth inhibition assays showed significant activity against all tested strains, with 50% inhibitory concentrations between 5 and 600nM and almost no toxic effect against host cells including healthy red blood cells. Fluorescence microscopy studies with a green-fluorescent ZnDPA probe showed selective targeting of infected red blood cells. The results suggest that ZnDPA coordination complexes are promising antiplasmodial agents with potential for targeted malaria treatment.

Indexed as

AnimalsAntimalarialsCell ProliferationCHO CellsCoordination ComplexesCricetinaeCricetulusErythrocytesHemolysisHumansMalariaMicroscopy, FluorescenceOrganometallic CompoundsPicolinesPlasmodium falciparumAntimalarialsCoordination ComplexesOrganometallic CompoundsPicolineszinc(II) dipicolylamineAntiplasmodial drugsFluorescence microscopyMalariaZinc dipicolylamine

Identifiers

PMID28377170
PMCPMC5443346
OpenAlexW2603669228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.