ArticleJournal of orthopaedic surgery and research2017
Incidence of venous thromboembolism and bleeding events in patients with lower extremity orthopedic surgery: a retrospective analysis of a Japanese healthcare database.
Article in Journal of orthopaedic surgery and research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Effectiveness and Safety of Aspirin Versus Other Antithrombotics for VTE After Total Hip and Knee Arthroplasty in Real-World Setting.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- A prospective cohort study protocol on sequential compression alone for the prevention of venous thromboembolism (VTE) in laparoscopic cholecystectomy.International journal of surgery protocols · 2026Article
- Frequency of deep vein thrombosis in patients undergoing total knee replacement using pneumatic tourniquet.Pakistan journal of medical sciences · 2026Article
- Analysis of the Reasons for Transferring Patients from Orthopedic Specialty Hospitals to Tertiary Hospitals After Surgery.Journal of clinical medicine · 2025Article
- Does Surgical Treatment of Varicose Veins Prior to Total Knee Arthroplasty Decrease Rates of Postoperative Venous Thromboembolism? A Matched Cohort Study.Journal of orthopaedics · 2025Article
- Research progress on the causes and countermeasures of postoperative swelling in gluteal muscle contracture.Frontiers in medicine · 2025Review
- Incidence and risk factors of perioperative deep vein thrombosis in patients undergoing primary hip arthroplasty via the direct anterior approach.Journal of orthopaedic surgery and research · 2024Article
- Incidence and preventive treatment for deep vein thrombosis with our own preventive protocol in total hip and knee arthroplasty.PloS one · 2024Article
- Combination of enoxaparin and low-dose aspirin for thromboprophylaxis in selective patients after primary total joint arthroplasty in a Taiwanese population.Journal of the Chinese Medical Association : JCMA · 2023Article
- Pulmonary Thromboembolism Developed During Hospitalization: A Nationwide Retrospective Observational Study Using Claims Data.Cardiology and therapy · 2023Article
- Effects of Perioperative Oral Management in Patients with Cancer.Journal of clinical medicine · 2022Article
- Context and Considerations for Use of Two Japanese Real-World Databases in Japan: Medical Data Vision and Japanese Medical Data Center.Drugs - real world outcomes · 2022Review
- Association between pre-admission anticoagulation and in-hospital death, venous thromboembolism, and major bleeding among hospitalized COVID-19 patients in Japan.Pharmacoepidemiology and drug safety · 2022Article
- Article
- Feasibility and Safety of a Novel Leg Exercise Apparatus for Venous Thromboembolism Prophylaxis after Total Joint Arthroplasty of the Lower Extremities-A Pilot Study.Tomography (Ann Arbor, Mich.) · 2021Article
- Current status survey of the extramural hospital management of venous thromboembolism after total hip and knee arthroplasty in China.BMC musculoskeletal disorders · 2021Article
- An Update on Venous Thromboembolism Rates and Prophylaxis in Hip and Knee Arthroplasty in 2020.Medicina (Kaunas, Lithuania) · 2020Review
- Surgical repair of acute Achilles tendon ruptures: a follow-up of 639 consecutive cases.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Article
- The effectiveness of a self-made modular elastic compression device for patients with a fracture of the tibia and fibula.Journal of orthopaedic surgery and research · 2020Article
- Pneumonia prevention effects of perioperative oral management in approximately 25,000 patients following cancer surgery.Clinical and experimental dental research · 2020Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrthopedic surgeries of lower extremities such as total knee arthroplasty (TKA), total hip arthroplasty (THA), and hip fracture surgery (HFS) are widely considered to carry a high risk of developing deep venous thrombosis (DVT) and pulmonary thromboembolism (PTE). Growing attention to epidemiological studies using a healthcare database led us to quantify the risks using a Japanese database to reveal recent medical care for such events.
methodsThe study comprised 36,947 patients who had undergone orthopedic surgeries of the lower extremities and whose medical information from April 2008 to September 2013 was available. The source population of the database was derived from 100 acute-care hospitals with Diagnosis Procedure Combination. The events were defined by diagnosis, medication, imaging, and laboratory tests.
resultsA breakdown of patients who underwent orthopedic surgeries by type of surgery showed 13.6% for TKA, 10.4% for THA, 56.8% for HFS, 1.5% for rupture of Achilles tendon, and 18.0% for simple fracture of lower extremities. The incidence for DVT, PTE, and bleeding events by type of surgery was 1.3, 0.2, and 1.0% for TKA; 0.9, 0.2, and 1.1% for THA; and 0.4, 0.1, and 1.8% for HFS, respectively. The population for risk factor analysis consisted of patients with similar background factors who underwent TKA, THA, or HFS. The statistically significant risk factors for PTE analyzed by the backward elimination procedure in a multivariate model were female sex, history of venous thromboembolism (VTE), thrombophilia, and varicose veins of lower extremity.
conclusionsThe incidence of DVT, PTE, and bleeding events and the risk factors for DVT and PTE in patients by type of orthopedic surgeries of lower extremities found in our study are considered to be rational as they reflect evidence from real-world cases.
trial registrationUniversity Hospital Medical Information Network Clinical Trials Registry UMIN000012667.
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