ArticleRadiation oncology (London, England)2017
An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma.
Article in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Evaluating the efficacy of biological versus physical cost functions with constrained mode for inverse plan optimization of head and neck cancer.Radiological physics and technology · 2025Article
- Dosimetric Advantage of Scanning Beam Proton Therapy in Gynecologic Patients Receiving Adjuvant Radiotherapy.Cancers · 2025Article
- Correlation between the setting of gating window width and setup accuracy in left breast cancer radiotherapy based on deep inspiration breath hold.Journal of applied clinical medical physics · 2023Observational
- Direct incorporation of patient-specific efficacy and toxicity estimates in radiation therapy plan optimization.Medical physics · 2022Article
- Dosimetric Comparison, Treatment Efficiency Estimation, and Biological Evaluation of Popular Stereotactic Radiosurgery Options in Treating Single Small Brain Metastasis.Frontiers in oncology · 2021Article
- Using biologically based objectives to optimize boost intensity-modulated radiation therapy planning for brainstem tumors in dogs.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2020Article
- Stereotactic body radiation therapy in primary hepatocellular carcinoma: current status and future directions.Journal of gastrointestinal oncology · 2018Review
- On the gEUD biological optimization objective for organs at risk in Photon Optimizer of Eclipse treatment planning system.Journal of applied clinical medical physics · 2018Article
- Dosimetric and Radiobiological Impact of Patient Setup Errors in Intensity-modulated Radiotherapy for Esophageal Cancer.Technology in cancer research & treatmentArticle
- Paradigm Shift in Radiation Treatment Planning Over Multiple Treatment Modalities.Journal of medical physicsReview
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8 authors.
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Abstract
backgroundFor cervical carcinoma cases, this study aimed to evaluate the quality of intensity-modulated radiation therapy (IMRT) plans optimized by biological constraints. Furthermore, a new integrated strategy in biological planning module was proposed and verified.
methodsTwenty patients of advanced stage cervical carcinoma were enrolled in this study. For each patient, dose volume optimization (DVO), biological model optimization (BMO) and integrated strategy optimization (ISO) plans were created using same treatment parameters. Different biological models were also used for organ at risk (OAR) in BMO plans, which include the LKB and Poisson models. Next, BMO plans were compared with their corresponding DVO plans, in order to evaluate BMO plan quality. ISO plans were also compared with DVO and BMO plans, in order to verify the performance of the integrated strategy.
resultsBMO plans produced slightly inhomogeneity and less coverage of planning target volume (PTV) (V95=96.79, HI = 0.10: p < 0.01). However, the tumor control probability (TCP) value, both from DVO and BMO plans, were comparable. For the OARs, BMO plans produced lower normal tissue complication probability (NTCP) of rectum (NTCP = 0.11) and bladder (NTCP = 0.14) than in the corresponding DVO plans (NTCP = 0.19 and 0.18 for rectum and bladder; p < 0.01 for rectum and p = 0.03 for bladder). V95, D98, CI and HI values that were produced by ISO plans (V95 = 98.31, D98 = 54.18Gy, CI = 0.76, HI = 0.09) were greatly better than BMO plans (V95 = 96.79, D98 = 53.42Gy, CI = 0.71, HI = 0.10) with significant differences. Furthermore, ISO plans produced lower NTCP values of rectum (NTCP = 0.14) and bladder (NTCP = 0.16) than DVO plans (NTCP = 0.19 and 0.18 for rectum and bladder, respectively) with significant differences.
conclusionsBMO plans produced lower NTCP values of OARs compared to DVO plans for cervical carcinoma cases, and resulted in slightly less target coverage and homogeneity. The integrated strategy, proposed in this study, could improve the coverage, conformity and homogeneity of PTV greater than the BMO plans, as well as reduce the NTCP values of OARs greater than the DVO plans.
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