ArticleBMC veterinary research2017
Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats.
Article in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Muscle Mass Is a Better Predictor of Survival in Dogs With Chronic Kidney Disease Compared to Body Condition Score.Journal of animal physiology and animal nutrition · 2026Article
- Unsupervised clustering of serum lipase activity in cats: a data-driven approach to correlate clinical, laboratory, and ultrasonographic findings.Journal of veterinary internal medicine · 2026Article
- Evidence of obesity-induced inflammatory changes in client-owned cats.Veterinary world · 2024Article
- Effects of five carbohydrate sources on cat diet digestibility, postprandial glucose, insulin response, and gut microbiomes.Journal of animal science · 2023Article
- Analytical performance of a canine ELISA monocyte chemoattractant protein-1 assay for use in cats and evaluation of circulating levels in normal weight and obese cats.Acta veterinaria Scandinavica · 2022Article
- Influence of high-protein and high-carbohydrate diets on serum lipid and fructosamine concentrations in healthy cats.Journal of feline medicine and surgery · 2022Article
- Changes in glucose tolerance and insulin secretion in a cohort of cats with chronic obesity.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Measures of insulin sensitivity, leptin, and adiponectin concentrations in cats in diabetic remission compared to healthy control cats.Frontiers in veterinary science · 2022Article
- Adipokines as potential biomarkers for type 2 diabetes mellitus in cats.Frontiers in immunology · 2022Review
- Article
- Association of circulating adipokine concentrations with indices of adiposity and sex in healthy, adult client owned cats.BMC veterinary research · 2019Article
- Adipokines secretion in feline primary adipose tissue culture in response to dietary fatty acids.BMC veterinary research · 2019Article
- Adiponectin is valuable in the diagnosis of acute heart failure with renal insufficiency.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles in the pathophysiology of feline diabetes mellitus are relatively unknown. Here, we determined the concentrations of circulating leptin, adiponectin, pro-inflammatory cytokines, glucagon, adropin, triglycerides, and cholesterol, in non-diabetic lean and overweight cats and newly diagnosed diabetic cats. Client-owned cats were recruited and assigned into 3 study groups: lean, overweight and diabetic. Fasting blood samples were analyzed in lean, overweight and diabetic cats at baseline and 4 weeks after consumption of high protein/low carbohydrate standardized diet.
resultsSerum concentrations of triglycerides were greater in diabetics at baseline and were increased in both diabetic and overweight cats at 4 weeks. Plasma leptin concentrations were greater in diabetic and overweight at baseline and 4 weeks, whereas adiponectin was lower in diabetics compared to lean and overweight cats at baseline and 4 weeks. Diabetics had greater baseline plasma glucagon concentrations compared to lean, lower adropin than overweight at 4 weeks, and lower IL-12 concentrations at 4 weeks than baseline.
conclusionsOur results suggest that feline obesity and diabetes mellitus are characterized by hypertriglyceridemia and hyperleptinemia; however, diabetic cats have significantly lower adiponectin and adropin compared to overweight cats. Thus, despite having similar body condition, overweight and diabetic cats have differential circulating concentrations of adiponectin and adropin.
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