Evidence map›Paper›PMID 28376824›Full record

ArticleBMC infectious diseases2017

Hepatitis C co-infection is associated with an increased risk of incident chronic kidney disease in HIV-infected patients initiating combination antiretroviral therapy.

Carmine Rossi, Janet Raboud, Sharon Walmsley, Curtis Cooper, Tony Antoniou, Ann N Burchell, Mark Hull, Jason Chia, Robert S Hogg, Erica E M Moodie and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. When do co-infections matter?Current opinion in infectious diseases · 2018
    Review
  14. Article
  15. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Carmine RossiResearch Institute of the McGill University Health Centre, Montréal, Canada.
Janet RaboudDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Sharon WalmsleyToronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Curtis CooperThe Ottawa Hospital, General Campus, Ottawa, Canada.
Tony AntoniouSt. Michael's Hospital, University of Toronto, Toronto, Canada.
Ann N BurchellSt. Michael's Hospital, University of Toronto, Toronto, Canada.
Mark HullBC Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Jason ChiaBC Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Robert S HoggBC Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Erica E M MoodieDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Canada.
Marina B KleinResearch Institute of the McGill University Health Centre, Montréal, Canada. marina.klein@mcgill.ca.
Canadian Observational Cohort (CANOC) Collaboration
AIDS Vancouver · CAMcGill University Health Centre · CASt. Michael's Hospital · CAToronto General Hospital · CAMcGill University · CAOttawa Hospital · CA

Funding

CIHR CIHR #02684CIHR CIHR #134047CIHR CIHR #143342CIHR CTN #242
6 · The paper itself

Abstract

backgroundCombination antiretroviral therapy (cART) has reduced mortality from AIDS-related illnesses and chronic comorbidities have become prevalent among HIV-infected patients. We examined the association between hepatitis C virus (HCV) co-infection and chronic kidney disease (CKD) among patients initiating modern antiretroviral therapy.

methodsData were obtained from the Canadian HIV Observational Cohort for individuals initiating cART from 2000 to 2012. Incident CKD was defined as two consecutive serum creatinine-based estimated glomerular filtration (eGFR) measurements <60 mL/min/1.73m

resultsWe included 2595 HIV-infected patients with eGFR >60 mL/min/1.73m

conclusionsHCV co-infection was associated with an increased risk of incident CKD among HIV-infected patients initiating cART. HCV-HIV co-infected patients should be monitored for kidney disease and may benefit from available HCV treatments.

Indexed as

CoinfectionAdultCanadaCohort StudiesFemaleGlomerular Filtration RateHepacivirusHepatitis CHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRenal Insufficiency, ChronicRisk FactorsAntiretroviral therapyChronic kidney diseaseCo-infectionGlomerular filtrationHepatitis CHIV

Identifiers

PMID28376824
PMCPMC5381089
OpenAlexW2605200881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.