ArticleBMC medical genetics2017
Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population.
Article in BMC medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Interplay between CDH1 polymorphisms, haplotypes, and genomic repetitive elements in urothelial bladder cancer prognosis.Molecular biology reports · 2026Article
- Cancer Diagnoses in Patients With Cleft Lip and/or Palate: Increased Childhood Cancer Occurrence.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts.Clinics (Sao Paulo, Brazil) · 2023Article
- Two tSNPs in BRIP1 are associated with breast cancer during TDT analysis.Molecular genetics & genomic medicine · 2021Article
- Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms.Genetic epidemiology · 2020Article
- Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia.Dentistry journal · 2020Article
- Genomic analyses in African populations identify novel risk loci for cleft palate.Human molecular genetics · 2019Article
- Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis.Medicina oral, patologia oral y cirugia bucal · 2018Observational
- Surgical rehabilitation of cleft lip and/or palate: evaluation of the Brazilian public health system.Brazilian journal of otorhinolaryngologyArticle
- Association of single nucleotide polymorphisms in AXIN2, BMP4, and IRF6 with Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population.Journal of applied oral science : revista FOBArticle
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological studies have indicated a higher incidence of breast and gastric cancer in patients with nonsyndromic cleft lip with or without cleft palate (NSCL ± P) and their relatives, which can be based on similar genetic triggers segregated within family with NSCL ± P.
methodsThis multicenter study evaluated the association of 9 single nucleotide polymorphisms (SNP) in AXIN2 and CDH1, representing genes consistently altered in breast and gastric tumors, with NSCL ± P in 223 trios (father, mother and patient with NSCL ± P) by transmission disequilibrium test (TDT).
resultsOur results showed that the minor A allele of rs7210356 (p = 0.01) and the T-G-G-A-G haplotype formed by rs7591, rs7210356, rs4791171, rs11079571 and rs3923087 SNPs (p = 0.03) in AXIN2 were significantly under-transmitted to patients with NSCL ± P. In CDH1 gene, the C-G-A-A and A-G-A-G haplotypes composed by rs16260, rs9929218, rs7186053 and rs4783573 polymorphisms were respectively over-transmitted (p = 0.01) and under-transmitted (p = 0.008) from parents to the children with NSCL ± P.
conclusionsThe results suggest that polymorphic variants in AXIN2 and CDH1 may be associated with NSCL ± P susceptibility, and reinforce the putative link between cancer and oral clefts.
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