Trial reportDepression and anxiety2017
History of sexual trauma moderates psychotherapy outcome for posttraumatic stress disorder.
Trial report in Depression and anxiety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00739765 (Psychotherapies for Chronic Post-Traumatic Stress Disorder), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychotherapies for Chronic Post-Traumatic Stress Disorder
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A Systematic Review of Evidence-Based Treatments for Adolescent and Adult Sexual Assault Victims.Journal of the American Psychiatric Nurses AssociationPooled it
- Interpersonal psychotherapy versus sertraline for women with posttraumatic stress disorder following recent sexual assault: a randomized clinical trial.European journal of psychotraumatology · 2022Trial
- Interpersonal Psychotherapy of Posttraumatic Stress Disorder for Veterans and Family Members: An Open Trial.Psychiatric services (Washington, D.C.) · 2021Trial
- Anterior hippocampal volume predicts affect-focused psychotherapy outcome.Psychological medicine · 2020Trial
- The relationship between recent PTSD secondary to sexual assault, hippocampal volume and resting state functional connectivity in adolescent girls.Neurobiology of stress · 2022Article
- Subjective and objective sleep quality in young women with posttraumatic stress disorder following sexual assault: a prospective study.European journal of psychotraumatology · 2021Article
- Posttraumatic Stress Disorder and Neuroprogression in Women Following Sexual Assault: Protocol for a Randomized Clinical Trial Evaluating Allostatic Load and Aging Process Acceleration.JMIR research protocols · 2020Article
- Pathways to post-traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults.Brain and behavior · 2020Article
- The Moderating Role of Child Maltreatment in Treatment Efficacy for Adolescent Depression.Journal of abnormal child psychology · 2020Article
- Optimising treatment decision rules through generated effect modifiers: a precision medicine tutorial.BJPsych open · 2019Article
- Interpersonal Psychotherapy for PTSD: Treating Trauma without Exposure.Journal of psychotherapy integration · 2019Article
- Attrition in Interpersonal Psychotherapy Among Women With Post-traumatic Stress Disorder Following Sexual Assault.Frontiers in psychology · 2019Article
- Effectiveness of interpersonal psychotherapy-trauma for depressed women with childhood abuse histories.Journal of consulting and clinical psychology · 2018Article
- Do Acute Benefits of Interpersonal Psychotherapy for Posttraumatic Stress Disorder Endure?Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundModerators of differential psychotherapy outcome for posttraumatic stress disorder (PTSD) are rare, yet have crucial clinical importance. We tested the moderating effects of trauma type for three psychotherapies in 110 unmedicated patients with chronic DSM-IV PTSD.
methodsPatients were randomized to 14 weeks of prolonged exposure (PE, N = 38), interpersonal psychotherapy (IPT, N = 40), or relaxation therapy (RT, N = 32). The Clinician-Administered PTSD Scale (CAPS) was the primary outcome measure. Moderator candidates were trauma type: interpersonal, sexual, physical. We fit a regression model for week 14 CAPS as a function of treatment (a three-level factor), an indicator of trauma type presence/absence, and their interactions, controlling for baseline CAPS, and evaluated potential confounds.
resultsThirty-nine (35%) patients reported sexual, 68 (62%) physical, and 102 (93%) interpersonal trauma. Baseline CAPS scores did not differ by presence/absence of trauma types. Sexual trauma as PTSD criterion A significantly moderated treatment effect: whereas all therapies had similar efficacy among nonsexually-traumatized patients, IPT had greater efficacy among sexually traumatized patients (efficacy difference with and without sexual trauma: IPT vs. PE and IPT vs. RT P's < .05), specifically in PTSD symptom clusters B and D (P's < .05).
conclusionsFew studies have assessed effects of varying trauma types on effects of differing psychotherapies. In this exploratory study, sexual trauma moderated PTSD outcomes of three therapies: IPT showed greater benefit for sexually traumatized patients than PE or RT. The IPT focuses on affect to help patients determine trust in their current environments may particularly benefit patients who have suffered sexual assault.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.