ArticleJournal of the National Cancer Institute2017
Burdensome Research Procedures in Trials: Why Less Is More.
Article in Journal of the National Cancer Institute, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The research burden of randomized controlled trial participation: a systematic thematic synthesis of qualitative evidence.BMC medicine · 2020Pooled it
- Real-Time Estimation of Arterial Partial Pressure of Carbon Dioxide in Patients Undergoing General Anesthesia: Predictive Modeling Study.JMIR medical informatics · 2025Article
- Decision making for invasive and non-invasive optional procedures within an acute HIV research cohort in Bangkok.Contemporary clinical trials communications · 2023Article
- Practical consideration for successful sequential tumor biopsies in first-in-human trials.Investigational new drugs · 2022Article
- Understanding factors contributing to participant satisfaction in stroke walking recovery clinical trials.Contemporary clinical trials communications · 2022Article
- Patient perspectives on window of opportunity clinical trials in early-stage breast cancer.Breast cancer research and treatment · 2022Article
- Therapeutic Misconception about Research Procedures: Does a Simple Information Chart Improve Understanding?Ethics & human research · 2022Article
- Implications of Research Biopsies in Clinical Trials.The oncologist · 2021Article
- Applications of liquid biopsy in the Pharmacological Audit Trail for anticancer drug development.Nature reviews. Clinical oncology · 2021Review
- Details of risk-benefit communication in informed consent documents for phase I/II trials.Clinical trials (London, England) · 2021Article
- Risk Assessment of Medical Study Procedures in the Documents Submitted to a Research Ethics Committee.Journal of empirical research on human research ethics : JERHRE · 2020Article
- Biomarker development for axial spondyloarthritis.Nature reviews. Rheumatology · 2020Review
- Umbrella and basket trials in oncology: ethical challenges.BMC medical ethics · 2019Article
- Biomarkers in early-phase trials: fundamental issues.Bioanalysis · 2018Article
- Tissue Acquisition in Clinical Trials-Essential for Progress.Journal of the National Cancer Institute · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A large volume of trials involve invasive, nontherapeutic research procedures, like organ biopsy or sham surgeries, that can pose risks comparable with the experimental treatment itself but that have no direct benefit for volunteers. Though such procedures can enhance the value of clinical investigations, recent studies suggest that many studies involving invasive, nontherapeutic research procedures are not well planned and reported; some studies suggest that their results are often not utilized in the planning of new investigations. This commentary offers recommendations for how investigators, sponsors, and ethics committees might improve evaluation and implementation of studies involving invasive nontherapeutic procedures. We conclude by urging more demanding scientific standards for the rationale, design, and reporting of burdensome, nontherapeutic research procedures-particularly where they involve risk of serious complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.