ArticlePloS one2017
Clinicopathological characteristics of duodenal epithelial neoplasms: Focus on tumors with a gastric mucin phenotype (pyloric gland-type tumors).
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Tumours of the duodenum and the ampulla of Vater: An overview of the key criteria for their classification, pathogenesis, and molecular assessment.Virchows Archiv : an international journal of pathology · 2026Review
- Submucosal-Predominant (Inverted-Type) Pyloric Gland Adenoma of the Duodenum Mimicking Malignancy.ACG case reports journal · 2026Article
- A case of duodenal pyloric gland adenoma with high-grade dysplasia arising from ectopic gastric mucosa.DEN open · 2026Article
- Duodenal Adenocarcinoma with a Gastric Phenotype Demonstrating a Rapidly Progressive Course.Internal medicine (Tokyo, Japan) · 2025Article
- Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection.Frontiers in oncology · 2025Article
- Clinicopathological and Genetic Features in Superficial Nonampullary Duodenal Epithelial Tumors.Gastroenterology research and practice · 2025Article
- A Rare Case of Signet Ring Cell Carcinoma Arising on Duodenal Brunner's Gland Hyperplasia Successfully Treated Via Endoscopic Resection.The Korean journal of helicobacter and upper gastrointestinal research · 2024Article
- Endoscopic Diagnosis of Epithelial Subtypes of Superficial Non-Ampullary Duodenal Epithelial Tumors using Magnifying Narrow-Band Imaging.Digestive diseases (Basel, Switzerland) · 2024Article
- Gastric foveolar adenoma in the duodenal bulb: case report.The Pan African medical journal · 2024Article
- Duodenal gastric-type neoplasm with uncertain malignant potential in a lipoma.Clinical journal of gastroenterology · 2023Article
- Article
- APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum.Journal of gastroenterology · 2021Article
- The mucin phenotype does not affect the endoscopic resection outcome of non-ampullary duodenal epithelial tumors.Endoscopy international open · 2021Article
- Association between Endoscopic Milk-White Mucosa, Epithelial Intracellular Lipid Droplets, and Histological Grade of Superficial Non-Ampullary Duodenal Epithelial Tumors.Diagnostics (Basel, Switzerland) · 2021Article
- Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations.International journal of molecular sciences · 2021Review
- Large duodenal pyloric gland adenoma successfully resected by endoscopic submucosal dissection.Clinical journal of gastroenterology · 2021Article
- Endoscopic and Clinicopathological Features of Superficial Non-Ampullary Duodenal Tumor Based on the Mucin Phenotypes.Digestion · 2021Article
- Application of pleural flaps in laparoscopic-thoracoscopic esophagectomy for esophageal cancer.Journal of thoracic disease · 2020Article
- Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features.Scientific reports · 2019Article
- Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors.World journal of gastroenterology · 2019Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEpithelial tumors less commonly occur in the duodenum than in the stomach or large intestine. The clinicopathological characteristics of duodenal epithelial tumors remain a matter of debate. We therefore studied resected specimens to investigate the clinicopathological characteristics of duodenal epithelial tumors. MATERIALS AND
methodsAmong duodenal epithelial tumors resected endoscopically or surgically in our hospital, we studied the clinicopathological characteristics of 110 adenomas or intramucosal carcinomas. The grade of atypia of all tumors was classified into 3 groups according to the World Health Organization (WHO) 2010 classification. The tumors were immunohistochemically evaluated to determine the frequency of differentiation toward fundic glands.
resultsAs for patient characteristics, there were 76 men (75.2%) and 25 women (24.8%), with a median age of 65 years (range, 34 to 84). The tumors most commonly arose in the first to second part of the duodenum. Many lesions were flat, and the median tumor diameter was 8.0 mm. The lesions were classified into 2 types according to mucin phenotype: intestinal-type tumors (98 lesions, 89.1%) and gastric-type tumors (12 lesions, 10.9%). Intestinal-type tumors were subdivided into 2 groups: tubular-type tumors (91 lesions, 82.7%) and tubulovillous-type tumors (7 lesions, 6.4%). Gastric-type tumors were classified into 2 types: foveolar type (3 lesions, 2.7%) and pyloric gland-type (PG) tumors (9 lesions, 8.2%). The grade of atypia was significantly higher in gastric-type tumors (p<0.01). PG tumors were gastric-type tumors characterized by pyloric glands and findings suggesting differentiation toward fundic glands.
conclusionsAbout 10% of the duodenal tumors had a gastric-type mucin phenotype. Gastric-type tumors showed high-grade atypia. In particular, PG tumors showed similarities to PG tumors of the stomach, such as differentiation toward fundic glands.
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