ArticlePLoS genetics2017
The time and place of European admixture in Ashkenazi Jewish history.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Tracing human genetic histories and natural selection with precise local ancestry inference.Nature communications · 2025Article
- Founder mutations and rare disease in the Arab world.Disease models & mechanisms · 2024Review
- Lactase deficiency in Russia: multiethnic genetic study.European journal of clinical nutrition · 2023Article
- Improving variant calling using population data and deep learning.BMC bioinformatics · 2023Article
- Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14Cell · 2022Article
- Genomes from a medieval mass burial show Ashkenazi-associated hereditary diseases pre-date the 12th century.Current biology : CB · 2022Article
- Revealing the recent demographic history of Europe via haplotype sharing in the UK Biobank.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals.PLoS genetics · 2022Article
- Crohn's Disease Susceptibility and Onset Are Strongly Related to ThreeJournal of clinical medicine · 2021Article
- Middle eastern genetic legacy in the paternal and maternal gene pools of Chuetas.Scientific reports · 2020Article
- Population-Specific Recombination Maps from Segments of Identity by Descent.American journal of human genetics · 2020Article
- European Roma groups show complex West Eurasian admixture footprints and a common South Asian genetic origin.PLoS genetics · 2019Article
- Loter: A Software Package to Infer Local Ancestry for a Wide Range of Species.Molecular biology and evolution · 2018Article
- The genetic variation in the R1a clade among the Ashkenazi Levites' Y chromosome.Scientific reports · 2017Article
- Editorial: Population Genetics of Worldwide Jewish People.Frontiers in genetics · 2017Article
- The Origins of Ashkenaz, Ashkenazic Jews, and Yiddish.Frontiers in genetics · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
The Ashkenazi Jewish (AJ) population is important in genetics due to its high rate of Mendelian disorders. AJ appeared in Europe in the 10th century, and their ancestry is thought to comprise European (EU) and Middle-Eastern (ME) components. However, both the time and place of admixture are subject to debate. Here, we attempt to characterize the AJ admixture history using a careful application of new and existing methods on a large AJ sample. Our main approach was based on local ancestry inference, in which we first classified each AJ genomic segment as EU or ME, and then compared allele frequencies along the EU segments to those of different EU populations. The contribution of each EU source was also estimated using GLOBETROTTER and haplotype sharing. The time of admixture was inferred based on multiple statistics, including ME segment lengths, the total EU ancestry per chromosome, and the correlation of ancestries along the chromosome. The major source of EU ancestry in AJ was found to be Southern Europe (≈60-80% of EU ancestry), with the rest being likely Eastern European. The inferred admixture time was ≈30 generations ago, but multiple lines of evidence suggest that it represents an average over two or more events, pre- and post-dating the founder event experienced by AJ in late medieval times. The time of the pre-bottleneck admixture event, which was likely Southern European, was estimated to ≈25-50 generations ago.
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