ArticlePloS one2017
Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Lung function in obese children and adolescents without respiratory disease: a systematic review.BMC pulmonary medicine · 2020Pooled it
- Article
- Risk factors for pulmonary function alterations in children with metabolic dysfunction-associated fatty liver disease.Scientific reports · 2025Article
- Obesity: Next game changer of allergic airway diseases?Clinical and translational medicine · 2025Review
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- A clinician's guide to effects of obesity on childhood asthma and into adulthood.Expert review of respiratory medicine · 2024Review
- Association of Body Mass Index and Exhaled Breath Nitric Oxide: A Cross-Sectional Analysis of Shahedieh Cohort Study.Tanaffos · 2024Article
- Article
- Association between Pulmonary Function and Body Composition in Children and Adolescents with and without Obesity.Journal of clinical medicine · 2022Article
- Pulmonary function in school-age children following intravitreal injection of bevacizumab for retinopathy of prematurity.Scientific reports · 2022Article
- The Effect of Obesity on Fractional Exhaled Nitric Oxide in School-Aged Children.Children (Basel, Switzerland) · 2022Article
- Association of childhood BMI trajectory with post-adolescent and adult lung function is mediated by pre-adolescent DNA methylation.Respiratory research · 2022Article
- Effect of body mass index (BMI) on pulmonary functions in children of 6-14 years of age: A cross-sectional study.Journal of family medicine and primary care · 2022Article
- Factors Influencing the Concentration of Exhaled Nitric Oxide (FeNO) in School Children Aged 8-9-Years-Old in Krakow, with High FeNO Values ≥ 20 ppb.Medicina (Kaunas, Lithuania) · 2022Article
- Review
- Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment.Nutrients · 2021Review
- Allergic diseases attributable to atopy in a population sample of Asian children.Scientific reports · 2021Article
- Prevalence of overweight and obesity, and associations with socio-demographic factors in Kuwait.BMC public health · 2021Article
- Relationship of Nutritional Status and Spirometric Parameters in Children with Bronchial Asthma.Sovremennye tekhnologii v meditsine · 2021Article
- Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma.Journal of asthma and allergy · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with lung function and FeNO in children is modified by atopy is unclear. The objective of this study was to examine the effect of excess weight on lung function parameters and FeNO among Asian children, with a particular focus on exploring the potential effect modification by atopy.
methodsWe investigated the effect of excess weight on lung function and FeNO in a population sample of 1,717 children aged 5 to 18 years and explored the potential modifying effect of atopy.
resultsThere were positive associations of body mass index (BMI) z-score with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF25-75) (all P<0.001), after controlling for confounders. The beta coefficient for FEV1 (0.084) was smaller than that for FVC (0.111). In contrast, a negative association was found between BMI z-score and FEV1/FVC ratio (P<0.001) and FeNO (P = 0.03). A consistent pattern of association for lung function variables was observed when stratifying by atopy. There was a negative association of BMI z-score with FeNO in atopic subjects (P = 0.006), but not in non-atopic subjects (P = 0.46).
conclusionsExcess weight disproportionately impacts lung volumes and airflow in children from the general population, independent of atopic status. Excess weight inversely affects FeNO in atopic but not in non-atopic children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.