ArticlePloS one2017
High risk of misinterpreting liver and spleen stiffness using 2D shear-wave and transient elastography after a moderate or high calorie meal.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Trial
- Splenic Steatopathy: A Clinical and Experimental Framework for Lipid-Associated Splenic Pathology.Clinical and experimental gastroenterology · 2026Review
- Nonalcoholic steatohepatitis: A comprehensive updated review of risk factors, symptoms, and treatment.Heliyon · 2024Review
- Postprandial splenic stiffness changes on magnetic resonance elastography in a young healthy population.NMR in biomedicine · 2024Article
- Factors other than fibrosis that increase measured shear wave velocity.World journal of gastroenterology · 2022Review
- Accuracy of controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) for assessing steatosis and fibrosis in non-alcoholic fatty liver disease: A systematic review and meta-analysis.EClinicalMedicine · 2022Article
- Simplification of 2D shear wave elastography by enlarged SWE box and multiple regions of interest in one acquisition.PloS one · 2022Article
- Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers.Scientific reports · 2021Article
- Fibroscan® probe selection for lean adults.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Spleen elastography in patients with Systemic sclerosis.Rheumatology international · 2021Article
- A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B.Microorganisms · 2020Review
- Elevated liver stiffness without histological evidence of liver fibrosis in rural Ugandans.Journal of viral hepatitis · 2020Article
- Liver-related effects of chronic hepatitis C antiviral treatment.World journal of gastroenterology · 2020Review
- Liver stiffness measured by acoustic radiation force impulse elastography predicted prognoses of hepatocellular carcinoma after radiofrequency ablation.Scientific reports · 2020Article
- Nonalcoholic fatty liver disease and portal hypertension.Exploration of medicine · 2020Article
- Review
- Effect of ultrafiltration during hemodialysis on hepatic and total-body water: an observational study.BMC nephrology · 2018Observational
- Managing portal hypertension in patients with liver cirrhosis.F1000Research · 2018Review
- Impact of Time-Restricted Feeding and Dawn-to-Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease.Gastroenterology research and practice · 2017Review
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food intake increases liver stiffness, but it is believed that liver stiffness returns to baseline two hours after a meal. The aim of this study was to investigate the impact of different sized meals on liver stiffness. Liver and spleen stiffness was measured with transient elastography (TE) and real-time 2-dimensional shear wave elastography (2D-SWE). Patients ingested a 625 kcal and a 1250 kcal liquid meal on two consecutive days. We measured liver and spleen elasticity, Controlled attenuation parameter (CAP) and portal flow at baseline and after 20, 40, 60, 120 and 180 minutes. Sixty patients participated, 83% with alcoholic liver disease. Twenty-eight patients had METAVIR fibrosis score F0-3 and 32 patients had cirrhosis. Liver stiffness, spleen stiffness and CAP increased after both meals for all stages of fibrosis. False positive 2D-SWE liver stiffness measurements caused 36% and 52% of patients with F0-3 fibrosis to be misclassified with higher stages of fibrosis after the moderate and high caloric meal. Likewise, 10% and 13% of compensated cirrhosis patients were misclassified with clinically significant portal hypertension after the two meals. We observed similar misclassification rates with TE. After three hours, liver stiffness remained elevated more than 20% from baseline in up to 50% of patients. IN
conclusionLiver stiffness, spleen stiffness and CAP increase after a meal across all stages of fibrosis and across elastography techniques. Up to half of patients may be misclassified with higher stages of fibrosis, if they are assessed after less than three hours fasting period.
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