ReviewAnnual review of biophysics2017
Rate Constants and Mechanisms of Protein-Ligand Binding.
Review in Annual review of biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Lactoferrin/κ-Carrageenan Interactions: Thermodynamic and Kinetic Insights through Surface Plasmon Resonance and Steady-State Fluorescence.ACS omega · 2026Article
- Negative cooperativity drives activity of capsid-directed antivirals against hepatitis B virus.Science advances · 2026Article
- A Grignard-mediated route to access 4-substituted-3-RSC advances · 2026Article
- Accelerated Ostwald Ripening by Chemical Activity.Journal of the American Chemical Society · 2025Article
- Article
- MobsPy: A programming language for biochemical reaction networks.PLoS computational biology · 2025Article
- Antihypertensive and Antidiabetic Drug Candidates from Milkfish (Foods (Basel, Switzerland) · 2024Article
- Computational design of an imine reductase: mechanism-guided stereoselectivity reversion and interface stabilization.Chemical science · 2024Article
- Nonspecific vs. specific DNA binding free energetics of a transcription factor domain protein.Biophysical journal · 2023Article
- A multiscale predictive digital twin for neurocardiac modulation.The Journal of physiology · 2023Article
- Site Identification by Ligand Competitive Saturation-Biologics Approach for Structure-Based Protein Charge Prediction.Molecular pharmaceutics · 2023Article
- Editorial: Mechanisms, thermodynamics and kinetics of ligand binding revealed from molecular simulations and machine learning.Frontiers in molecular biosciences · 2023Article
- Interplay of Affinity and Surface Tethering in Protein Recognition.The journal of physical chemistry letters · 2022Article
- Classification of protein-protein association rates based on biophysical informatics.BMC bioinformatics · 2021Article
- The Effects of Temperature and Pressure on Protein-Ligand Binding in the Presence of Mars-Relevant Salts.Biology · 2021Article
- Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions.The Biochemical journal · 2021Article
- Molecular Mechanics Study of Flow and Surface Influence in Ligand-Protein Association.Frontiers in molecular biosciences · 2021Article
- Markov State Models to Elucidate Ligand Binding Mechanism.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Understanding the Impacts of Conformational Dynamics on the Regulation of Protein-Protein Association by a Multiscale Simulation Method.Journal of chemical theory and computation · 2020Article
- Sequence-Dependent Correlated Segments in the Intrinsically Disordered Region of ChiZ.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Whereas protein-ligand binding affinities have long-established prominence, binding rate constants and binding mechanisms have gained increasing attention in recent years. Both new computational methods and new experimental techniques have been developed to characterize the latter properties. It is now realized that binding mechanisms, like binding rate constants, can and should be quantitatively determined. In this review, we summarize studies and synthesize ideas on several topics in the hope of providing a coherent picture of and physical insight into binding kinetics. The topics include microscopic formulation of the kinetic problem and its reduction to simple rate equations; computation of binding rate constants; quantitative determination of binding mechanisms; and elucidation of physical factors that control binding rate constants and mechanisms.
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Registered trials
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